Case and Research Letter
Impact of Finasteride and Dutasteride in Beard Thickness in Men With Androgenetic Alopecia: A 453-patient Retrospective Trial
Impacto del uso de finasterida y dutasterida en el grosor de la barba de hombres con alopecia androgenética: un estudio retrospectivo de 453 pacientes
Read
2724
Timeswas read the article
486
Total PDF
2238
Total HTML
Share statistics
array:22 [ "pii" => "S000173102400591X" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.05.046" "estado" => "S200" "fechaPublicacion" => "2024-09-04" "aid" => "4035" "copyrightAnyo" => "2024" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S000173102400601X" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.06.010" "estado" => "S200" "fechaPublicacion" => "2024-09-05" "aid" => "4030" "copyright" => "AEDV" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Parental Assessment of Infantile Hemangioma Cosmetic Clinical Outcomes: Results of the Spanish Hemangioma Nationwide Prospective Cohort" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:3 [ 0 => "en" 1 => "en" 2 => "es" ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación parental de los resultados estéticos de los hemangiomas infantiles: resultados de la cohorte prospectiva española de hemangiomas infantiles" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0020" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 1085 "Ancho" => 630 "Tamanyo" => 108098 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Colmenero-Sendra, J. del Boz-González, E. Baselga Torres, J. Bernabéu-Wittel, E. Roé-Crespo, A. Vicente, M. Valdivieso-Ramos, A. Martín-Santiago, S.I. Palencia-Pérez, M.T. Montserrat-García, A. Azón-Masoliver, M. Dañino, C. Tubau Prims, C. Prat, A. Giacaman, J.J. Domínguez-Cruz, A. Bauzá Alonso, M. Grau-Pérez, M.Á. Descalzo, I. García-Doval" "autores" => array:20 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Colmenero-Sendra" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "del Boz-González" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Baselga Torres" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Bernabéu-Wittel" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Roé-Crespo" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Vicente" ] 6 => array:2 [ "nombre" => "M." "apellidos" => "Valdivieso-Ramos" ] 7 => array:2 [ "nombre" => "A." "apellidos" => "Martín-Santiago" ] 8 => array:2 [ "nombre" => "S.I." "apellidos" => "Palencia-Pérez" ] 9 => array:2 [ "nombre" => "M.T." "apellidos" => "Montserrat-García" ] 10 => array:2 [ "nombre" => "A." "apellidos" => "Azón-Masoliver" ] 11 => array:2 [ "nombre" => "M." "apellidos" => "Dañino" ] 12 => array:2 [ "nombre" => "C." "apellidos" => "Tubau Prims" ] 13 => array:2 [ "nombre" => "C." "apellidos" => "Prat" ] 14 => array:2 [ "nombre" => "A." "apellidos" => "Giacaman" ] 15 => array:2 [ "nombre" => "J.J." "apellidos" => "Domínguez-Cruz" ] 16 => array:2 [ "nombre" => "A." "apellidos" => "Bauzá Alonso" ] 17 => array:2 [ "nombre" => "M." "apellidos" => "Grau-Pérez" ] 18 => array:2 [ "nombre" => "M.Á." "apellidos" => "Descalzo" ] 19 => array:2 [ "nombre" => "I." "apellidos" => "García-Doval" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0020"></elsevierMultimedia></p></span>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102400601X?idApp=UINPBA000044" "url" => "/00017310/unassign/S000173102400601X/v2_202409060714/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S0001731023004908" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.05.022" "estado" => "S200" "fechaPublicacion" => "2023-07-18" "aid" => "3547" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Recalcitrant Hailey–Hailey Disease With Satisfactory Response to Apremilast" "tienePdf" => "en" "tieneTextoCompleto" => "en" "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Hailey-Hailey recalcitrante con respuesta satisfactoria a apremilast" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2049 "Ancho" => 1555 "Tamanyo" => 362161 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Red-brown plaques with superficial erosions and a macerated appearance, located in the axillary folds (A) and groin (B) before the start of treatment with apremilast. Note the improvement of the lesions after 6 months of treatment with apremilast 30<span class="elsevierStyleHsp" style=""></span>mg twice a day (C and D).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Mansilla-Polo, C. Abril-Pérez, M.Á. Navarro-Mira, R. Botella-Estrada" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Mansilla-Polo" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Abril-Pérez" ] 2 => array:2 [ "nombre" => "M.Á." "apellidos" => "Navarro-Mira" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Botella-Estrada" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023004908?idApp=UINPBA000044" "url" => "/00017310/unassign/S0001731023004908/v1_202307180913/en/main.assets" ] "asociados" => array:1 [ 0 => array:16 [ "pii" => "S0001731024008135" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.10.039" "estado" => "S100" "fechaPublicacion" => "2024-10-25" "aid" => "4130" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => " Impacto del uso de finasterida y dutasterida en el grosor de la barba de hombres con alopecia androgenética: un estudio retrospectivo de 453 pacientes" "tienePdf" => "es" "tieneTextoCompleto" => "es" "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Impact of Finasteride and Dutasteride in Beard Thickness in Men With Androgenetic Alopecia: A 453-patient Retrospective Trial" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "O.M. Moreno-Arrones, D. Saceda-Corralo, D. Ortega-Quijano, A. Hermosa-Gelbard, S. Vañó-Galván" "autores" => array:5 [ 0 => array:2 [ "nombre" => "O.M." "apellidos" => "Moreno-Arrones" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "Saceda-Corralo" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "Ortega-Quijano" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Hermosa-Gelbard" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Vañó-Galván" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024008135?idApp=UINPBA000044" "url" => "/00017310/unassign/S0001731024008135/v1_202410250438/es/main.assets" ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Impact of Finasteride and Dutasteride in Beard Thickness in Men With Androgenetic Alopecia: A 453-patient Retrospective Trial" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>," "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "O.M. Moreno-Arrones, D. Saceda-Corralo, D. Ortega-Quijano, A. Hermosa-Gelbard, S. Vañó-Galván" "autores" => array:5 [ 0 => array:4 [ "nombre" => "O.M." "apellidos" => "Moreno-Arrones" "email" => array:1 [ 0 => "o.m.m.arrones@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "D." "apellidos" => "Saceda-Corralo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "D." "apellidos" => "Ortega-Quijano" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Hermosa-Gelbard" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "S." "apellidos" => "Vañó-Galván" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Dermatology Department, Trichology Unit, Ramon y Cajal University Hospital, University of Alcala, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Trichology and Hair Transplantation Unit, Grupo Pedro Jaen Clinic, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Impacto del uso de finasterida y dutasterida en el grosor de la barba de hombres con alopecia androgenética: un estudio retrospectivo de 453 pacientes" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A common inquiry from the ever-increasing informed patient is whether 5-alpha-reductase inhibitors (5ARIs) (i.e., finasteride and dutasteride) in the context of managing male androgenetic alopecia (AGA) can hinder beard growth. The development of the beard is included by the acquisition of secondary sexual characteristics in boys, fundamentally determined by the sex steroids testosterone, dihydrotestosterone (DHT), other adrenal androgens and estradiol. It is not uncommon that complete growth of the adult male beard can be delayed until he is 25 years of age, despite the fact that adult testosterone concentrations in blood are reached by the age of 15.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> It is precisely within the second decade of life when patients with incipient alopecia go to their dermatologist and are usually prescribed 5ARIs. Both finasteride and dutasteride can partially reverse the miniaturization process characteristic of AGA by limiting the transformation of testosterone into its higher potency metabolite DHT blocking the action of the 5-alpha-reductase enzyme.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2,3</span></a> The objective of this study was to see whether the use of 5ARI was associated with a decrease in beard thickness in male patients.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We retrospectively compared the clinical pictures of male patients younger than 35 years who received 5ARI monotherapy for, at least, 12 months. Patients were asked to trim their beards similar to their first visit at their follow-up visits. Inclusion criterion was the presence of a stablished beard within the first visit defined as having a beard developed similarly to the patient's father. Beard thickness was evaluated as increased, stable or decreased vs the basal visit based on clinical pictures.</p><p id="par0015" class="elsevierStylePara elsevierViewall">A total of 453 patients with a mean age of 24.6 years (range, 16–35) were included. Finasteride 1<span class="elsevierStyleHsp" style=""></span>mg was prescribed daily to total of 100 patients (22.1%) while the remaining patients (353, 77.9%) were prescribed dutasteride 0.5<span class="elsevierStyleHsp" style=""></span>mg, also daily. Most patients (439, 96.9%) experienced no changes, in 5 patients (1.1%) beard thickness decreased, while in 9 patients (1.9%) it increased (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">These results support the clinical suspicion that 5ARIs do not seem to decrease beard thickness. Studies in transgender (male to female) patients have found that beard growth is extremely resistant to estrogen and antiandrogen (e.g. cyproterone acetate) treatment.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Additionally, it has been hypothesized that circulating androgens are not completely needed to sustain male hair growth once it has been established as some authors have described that beard tends to persist years after complete orchiectomy in male to female individuals.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Furthermore, 5ARIs are not considered pure antiandrogenic drugs as they do not decrease testosterone serum levels<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> which can interact with the intracellular androgen receptors (AR) present in hair follicles and promote beard growth even with low levels of DHT. The main limitation of this study is that only clinical beard thickness was evaluated but no trichoscopic hair measurements were taken due to the study retrospective design.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion, the use of 5ARIs in men with stablished beard does not seem to have detrimental effects on beard thickness.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author declares that there is no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Beard thickness evolution</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Improvement \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Worsening \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Stability \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Finasteride 1<span class="elsevierStyleHsp" style=""></span>mg daily \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94 (94%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dutasteride 0.5<span class="elsevierStyleHsp" style=""></span>mg daily \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (1.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">345 (97.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3643139.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Beard thickness evolution after a year of treatment.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.S. Parent" 1 => "G. Teilmann" 2 => "A. Juul" 3 => "N.E. Skakkebaek" 4 => "J. Toppari" 5 => "J.P. Bourguignon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/er.2002-0019" "Revista" => array:5 [ "tituloSerie" => "Endocr Rev" "fecha" => "2003" "volumen" => "24" "paginaInicial" => "668" "paginaFinal" => "693" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "5-Alpha reductase inhibitors in androgenetic alopecia: shifting paradigms, current concepts, comparative efficacy, and safety" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Dhurat" 1 => "A. Sharma" 2 => "L. Rudnicka" 3 => "G. Kroumpouzos" 4 => "M. Kassir" 5 => "H. Galadari" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dth.13379" "Revista" => array:3 [ "tituloSerie" => "Dermatol Ther" "fecha" => "2020" "volumen" => "33" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness and safety of oral dutasteride for male androgenetic alopecia in real clinical practice: a descriptive monocentric study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Vañó-Galván" 1 => "D. Saceda-Corralo" 2 => "O.M. Moreno-Arrones" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dth.13182" "Revista" => array:4 [ "tituloSerie" => "Dermatol Ther" "fecha" => "2020" "volumen" => "33" "paginaInicial" => "e13182" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.J. Giltay" 1 => "L.J.G. Gooren" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.85.8.6710" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2000" "volumen" => "85" "paginaInicial" => "2913" "paginaFinal" => "2921" "itemHostRev" => array:3 [ "pii" => "S1556086422014964" "estado" => "S300" "issn" => "15560864" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of dutasteride on serum free-testosterone and clinical significance of testosterone changes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Enatsu" 1 => "H. Miyake" 2 => "T. Haraguchi" 3 => "K. Chiba" 4 => "M. Fujisawa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/and.12560" "Revista" => array:5 [ "tituloSerie" => "Andrologia" "fecha" => "2016" "volumen" => "48" "paginaInicial" => "1195" "paginaFinal" => "1201" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/unassign/S000173102400591X/v1_202409040422/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/00017310/unassign/S000173102400591X/v1_202409040422/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102400591X?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 115 | 22 | 137 |
| 2024 October | 982 | 140 | 1122 |
| 2024 September | 737 | 102 | 839 |
| 2024 August | 334 | 105 | 439 |
| 2024 July | 70 | 117 | 187 |
