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hay datos que permiten sostener que habr&#237;a posibilidades adicionales de contagio a trav&#233;s de las relaciones sexuales&#46; Por una parte&#44; el ARN de este virus se ha detectado en muestras de saliva y de mucosa oral<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">3</span></a>&#46; Adem&#225;s&#44; las c&#233;lulas de la mucosa oral y far&#237;ngea pueden ser susceptibles a la infecci&#243;n&#44; ya que expresan receptores de enzima convertidora de la angiotensina tipo 2 &#40;ECA-2&#41;&#44; lo que podr&#237;a indicar que la infecci&#243;n se transmite por besos&#44; aunque probablemente esto tenga menor importancia en el contexto de la transmisi&#243;n respiratoria del virus<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">4</span></a>&#46; Por otra parte&#44; tambi&#233;n se ha detectado ARN en las c&#233;lulas de las mucosas intestinal y rectal&#44; adem&#225;s de haberse demostrado la eliminaci&#243;n fecal del SARS-CoV-2&#44; que seg&#250;n algunas series se mantiene m&#225;s tiempo que la eliminaci&#243;n respiratoria de virus<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">5&#44;6</span></a>&#46; A estas pruebas se suma el hecho de haber llegado a detectar ARN viral en la vagina<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">7</span></a>&#44; as&#237; como la posibilidad &#40;aunque baja&#41; de transmisi&#243;n vertical madre-hijo<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">8</span></a>&#46; A pesar de ello&#44; en las primeras fases de la pandemia no se encontr&#243; ARN viral en muestras de semen de hombres en fase aguda de la infecci&#243;n ni en fase de recuperaci&#243;n&#44; ni tampoco en muestras de test&#237;culo de un hombre fallecido por COVID-19<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">9</span></a>&#46; La poblaci&#243;n sexualmente activa es un grupo de especial inter&#233;s para estudiar el posible contagio por v&#237;a sexual&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cabr&#237;a considerar&#44; pues&#44; que las personas con m&#250;ltiples contactos sexuales&#44; y especialmente aquellas involucradas en la prostituci&#243;n&#44; pueden tener aumentado el riesgo de COVID-19<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">10</span></a>&#44; tanto por el posible contagio sexual como por la cercan&#237;a f&#237;sica que implican las relaciones sexuales<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">11</span></a>&#46; La crisis econ&#243;mica que se ha producido relacionada con la epidemia de covid-19&#44; muy acusada en la ciudad de Madrid<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a>&#44; puede haber aumentado la vulnerabilidad de ciertos colectivos&#44; como el de las personas que ejercen la prostituci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">13&#44;14</span></a>&#44; al empujarlas a asumir riesgos de contagio &#40;de la propia infecci&#243;n por SARS-CoV-2 y de infecciones de transmisi&#243;n sexual&#44; ITS&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se han puesto en pr&#225;ctica distintas medidas preventivas durante la pandemia de COVID-19&#46; Antes de la aparici&#243;n de las vacunas muchas de ellas se centraron en la distancia social o las restricciones de movilidad&#46; Evaluar diferentes medidas de protecci&#243;n suele ser &#250;til en la fase de aprendizaje tras una crisis&#46; Los grupos de poblaci&#243;n sexualmente activa pueden tener un comportamiento particular respecto de las restricciones y medidas de prevenci&#243;n&#44; lo cual es relevante de cara a plantear medidas o mensajes focalizados&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Los objetivos del presente estudio son&#58; estimar la seroprevalencia de anticuerpos frente al virus SARS-CoV-2 en personas sexualmente activas atendidas en un servicio de ITS y analizar los factores sociales y preventivos relacionados con la infecci&#243;n por el SARS-CoV-2&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material y m&#233;todo</span><p id="par0030" class="elsevierStylePara elsevierViewall">Estudio observacional de corte transversal que incluy&#243; a todos aquellos pacientes mayores de 18 a&#241;os atendidos en la consulta monogr&#225;fica de ITS &#40;para estudio o cribado&#44; independientemente de la presencia o no de s&#237;ntomas de ITS&#41;&#44; no vacunados contra la COVID-19&#44; que firmaron un consentimiento para su inclusi&#243;n en el per&#237;odo del 10 de marzo al 21 de abril de 2021&#46; Haciendo uso del programa estad&#237;stico Epi-Info&#174; &#40;CDC&#44; Atlanta&#44; EE&#46;&#160;UU&#46;&#41;&#44; se calcul&#243; un tama&#241;o muestral necesario para la estimaci&#243;n de seroprevalencia de 500 pacientes&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Adem&#225;s de las exploraciones diagn&#243;sticas convencionales necesarias para el estudio o cribado de ITS&#44; se hizo una entrevista a los participantes sobre variables demogr&#225;ficas&#44; epidemiol&#243;gicas y conductuales&#44; y se realiz&#243; un test r&#225;pido de detecci&#243;n cualitativa de anticuerpos IgG e IgM frente al virus SARS-CoV-2 de Joysbio Technology&#174; &#40;Tianjin&#44; China&#44; lote 2020033006&#44; con 92&#44;4&#37; de sensibilidad y 94&#44;4&#37; de especificidad seg&#250;n los estudios remitidos en el momento de su adquisici&#243;n&#41; mediante la obtenci&#243;n de sangre capilar por digitopunci&#243;n&#46; En caso de darse un resultado que generase sospecha de infecci&#243;n activa por SARS-CoV-2&#44; se realiz&#243; test de detecci&#243;n de ant&#237;genos&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">El probable antecedente de infecci&#243;n por SARS-CoV-2 se defini&#243; bas&#225;ndose en la reactividad de la prueba serol&#243;gica r&#225;pida o en el antecedente de pruebas positivas para SARS-CoV-2 previas dentro del marco temporal pand&#233;mico&#46; A efectos de an&#225;lisis adicionales&#44; se defini&#243; a&#241;adiendo&#44; a los 2<span class="elsevierStyleHsp" style=""></span>criterios anteriores&#44; la presencia de s&#237;ntomas compatibles con COVID-19&#46; Aparte de las variables demogr&#225;ficas&#44; como el pa&#237;s de procedencia&#44; edad y sexo biol&#243;gico&#44; se recogieron variables sobre comportamientos como la orientaci&#243;n sexual&#44; el n&#250;mero de parejas sexuales&#44; la realizaci&#243;n de sexo transaccional&#44; consumo de alcohol&#44; pr&#225;ctica de <span class="elsevierStyleItalic">chemsex</span><a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">15</span></a>&#44; el uso de mascarilla durante las relaciones sexuales y el tipo de mascarilla utilizada habitualmente&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El cuaderno de recogida de datos en papel fue recodificado en una hoja de c&#225;lculo anonimizada para la gesti&#243;n de datos&#46; El estudio fue aprobado por el Comit&#233; de &#201;tica de la Investigaci&#243;n con Medicamentos del Hospital Universitario de la Princesa &#40;n&#250;mero de registro 4401&#44; c&#243;digo COVID19&#44; decisi&#243;n favorable de fecha 25-02-21&#44; acta CEIm 04&#47;21&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico se realiz&#243; con el programa R versi&#243;n 4&#46;1&#46;2&#46; Las variables categ&#243;ricas se expresaron como frecuencias&#44; la edad se describi&#243; con la media y desviaci&#243;n est&#225;ndar y el n&#250;mero de parejas sexuales a trav&#233;s de la mediana y el rango intercuart&#237;lico&#46; Para los contrastes de hip&#243;tesis en variables categ&#243;ricas se emple&#243; el test &#967;<span class="elsevierStyleSup">2</span>&#44; para la edad la t de Student y para el n&#250;mero de parejas sexuales el test de Wilcoxon-Mann-Whitney&#46; Se ajustaron 2<span class="elsevierStyleHsp" style=""></span>modelos de regresi&#243;n log&#237;stica binaria para la infecci&#243;n por SARS-CoV-2&#58; el principal&#44; utilizando como variable dependiente la seropositividad en prueba r&#225;pida o pruebas positivas previas&#44; y otro&#44; utilizando como variable dependiente la presencia de s&#237;ntomas compatibles&#46; En algunas trabajadoras sexuales no se pudo recoger el n&#250;mero de parejas sexuales&#44; por lo que se imputaron los valores perdidos con la mediana del grupo&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">Durante el per&#237;odo referido se realizaron 1&#46;018 visitas en consulta m&#233;dica&#44; correspondientes a 734 pacientes&#44; de los cuales 512 aceptaron ser incluidos en el estudio&#46; La <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> muestra el diagrama de flujo de inclusi&#243;n de pacientes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Un total de 124 pacientes &#40;24&#44;2&#37;&#41; tuvieron un resultado positivo en la prueba r&#225;pida serol&#243;gica o antecedentes de pruebas positivas de SARS-CoV-2 en el a&#241;o anterior&#46; Sumados aquellos que tuvieron s&#237;ntomas espec&#237;ficos de COVID-19 que no se pudieron hacer pruebas&#44; el n&#250;mero se elevaba a 208 pacientes &#40;40&#44;7&#37;&#41;&#46; Las pruebas serol&#243;gicas r&#225;pidas fueron reactivas en 24 pacientes&#44; 23 con IgG positiva y una con IgM positiva y prueba r&#225;pida de ant&#237;geno negativa&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se muestran las caracter&#237;sticas de los participantes y sus pr&#225;cticas de modo global y estratificados seg&#250;n de la presencia de serolog&#237;a positiva para coronavirus&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">En el an&#225;lisis bivariado se relacionaron con la serolog&#237;a positiva el uso de mascarillas distintas a las FFP2 y el n&#250;mero de parejas sexuales&#46; El tipo de mascarilla utilizada no se distribuy&#243; de modo aleatorio en la muestra&#58; las mascarillas FFP2 o asimilables fueron menos utilizadas por personas no europeas y personas que ejerc&#237;an la prostituci&#243;n&#46; La media de edad fue&#44; adem&#225;s&#44; ligeramente mayor en las personas que usaron mascarillas FFP2 o asimilables&#46; No encontramos relaci&#243;n entre el tipo de mascarilla utilizada y las pr&#225;cticas de su uso &#40;por ejemplo&#44; usarlas solo para evitar multas&#41;&#44; ni con su uso durante las relaciones sexuales &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Un subgrupo particular del estudio fue el de las 71 personas que ejerc&#237;an la prostituci&#243;n&#46; De ellas&#44; el 80&#37; eran mujeres cisg&#233;nero&#44; el 11&#37; hombres cisg&#233;nero y el 8&#44;5&#37; mujeres transg&#233;nero&#46; El 94&#44;4&#37; eran de origen no europeo y el 5&#44;6&#37; de origen europeo&#46; Solo el 11&#44;3&#37; us&#243; mascarillas tipo FFP2 o asimilables&#46; El 19&#44;7&#37; declar&#243; utilizar la mascarilla para evitar sanciones&#44; de forma similar al resto de la muestra&#46; Su mediana de parejas sexuales en los &#250;ltimos 3 meses fue de 80&#44; y en el &#250;ltimo a&#241;o 270&#44; claramente superior al resto de la muestra&#46; Hubo personas que disminuyeron o interrumpieron la prostituci&#243;n durante la pandemia&#58; 9 personas tuvieron 10 o menos parejas en los 3 meses previos al estudio&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Durante la atenci&#243;n a los pacientes se diagnosticaron diferentes infecciones de transmisi&#243;n sexual&#44; que se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46; Ninguna de ellas se identific&#243; con mayor frecuencia entre los pacientes con pruebas positivas para SARS-CoV-2&#46; El 10&#37; ten&#237;a infecci&#243;n por VIH conocida previamente y solo un paciente fue diagnosticado de VIH durante el estudio&#46; En el 6&#37; se identific&#243; s&#237;filis que requiri&#243; tratamiento&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">El n&#250;mero de parejas sexuales no sigui&#243; una distribuci&#243;n normal ni pudo asimilarse a la normalidad mediante logaritmos&#44; por lo que se categoriz&#243; seg&#250;n la mediana &#40;2 parejas sexuales en los &#250;ltimos 3 meses&#41;&#46; En el an&#225;lisis multivariante tener m&#225;s de la mediana de parejas sexuales se relacion&#243; con un resultado positivo para SARS-CoV-2 con una <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; de 1&#44;80 &#40;intervalo de confianza del 95&#37; &#91;IC&#160;95&#37;&#93;&#58; 1&#44;13-2&#44;88&#41; respecto de los pacientes que tuvieron la mediana o menos parejas&#46; El uso de mascarillas FFP2 fue protector&#44; con una OR de 0&#44;50 &#40;IC&#160;95&#37;&#58; 0&#44;28-0&#44;89&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Se relacionaron con la positividad o la presencia de s&#237;ntomas compatibles &#40;casos probables&#41; el n&#250;mero de parejas sexuales en los &#250;ltimos 3 meses&#44; con OR 1&#44;99 &#40;IC&#160;95&#37;&#58; 1&#44;32-3&#44;01&#41; y las mascarillas FFP2&#44; con OR 0&#44;49 &#40;IC&#160;95&#37;&#58; 0&#44;31-0&#44;79&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> se muestra el c&#225;lculo mediante suavizado de gr&#225;fica de dispersi&#243;n ponderada localmente &#40;<span class="elsevierStyleItalic">Locally weighted scatterplot smoothing</span>&#44; LOWESS&#41; de la probabilidad de obtener un resultado positivo de pruebas de SARS-CoV-2 respecto del n&#250;mero de parejas sexuales y el tipo de mascarilla utilizado&#46; La l&#237;nea vertical representa el percentil 75 &#40;8 parejas sexuales&#41;&#44; la estimaci&#243;n no es valorable en la cola de la distribuci&#243;n&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">La seroprevalencia global estimada de SARS-CoV-2 entre las personas con ITS o en riesgo de ITS atendidas en nuestro servicio monogr&#225;fico municipal es elevada &#40;24&#44;2&#37; en marzo-abril de 2021&#41;&#44; mayor que la estimada en el estudio m&#225;s cercano en el tiempo tanto en la Comunidad de Madrid &#40;18&#44;6&#37;&#59; IC&#160;95&#37;&#58; 16&#44;7-20&#44;6&#41;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">16</span></a> como en Espa&#241;a &#40;9&#44;9&#37;&#59; IC&#160;95&#37;&#58; 9&#44;4-10&#44;4&#41;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">17</span></a>&#46; Las caracter&#237;sticas que se relacionaron con la presencia de pruebas positivas fueron el uso de mascarillas que no fueran FFP2 y el mayor n&#250;mero de parejas sexuales&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">El uso de mascarillas sin filtro &#40;esto es&#44; no FFP2 o asimilables&#41; duplic&#243; el riesgo de contagio&#44; mientras que el n&#250;mero de parejas sexuales mayor a la mediana aument&#243; el riesgo un 80&#37;&#46; El uso de mascarillas FFP2 fue diferente en los distintos colectivos de la muestra&#58; fue llamativamente menos frecuente en un colectivo vulnerable como el de las personas que realizan sexo transaccional&#44; la mayor&#237;a de las cuales son no europeas&#46; No se relacion&#243; ninguna ITS con la presencia de pruebas positivas a SARS-CoV-2&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">En la estimaci&#243;n de la probabilidad de contagio mediante LOWESS facetada por parejas sexuales y uso de mascarillas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; se observa que el grupo de personas que usaron mascarillas FFP2 y no ten&#237;an parejas sexuales o ten&#237;an muy pocas presentaron un riesgo de contagio bajo&#44; a diferencia de las que utilizaron mascarillas no FFP2&#44; en que el riesgo era superior al 25&#37; incluso en personas sin parejas sexuales&#46; El riesgo aumenta en las personas que utilizan mascarillas FFP2 cuando hay m&#225;s parejas sexuales que la mediana&#46; Al interpretar esta gr&#225;fica debe tenerse en cuenta que el n&#250;mero de parejas sexuales es una variable con una cola a la derecha extraordinariamente larga&#44; con una cantidad peque&#241;a de personas que tiene un n&#250;mero alto de parejas sexuales&#58; en esta &#225;rea&#44; las estimaciones de la probabilidad de contagio son inestables y la informaci&#243;n es m&#225;s fiable en el &#225;rea izquierda del gr&#225;fico&#44; donde est&#225; la mayor&#237;a de los pacientes&#46; Sin embargo&#44; incluso en los pacientes con gran n&#250;mero de parejas sexuales no se observa un claro impacto en la estimaci&#243;n de la probabilidad de contagio&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En conjunto&#44; estas observaciones reafirman la importancia de la v&#237;a respiratoria para el contagio del SARS-CoV-2<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">1</span></a>&#44; dada la efectividad de las mascarillas faciales con filtro en su prevenci&#243;n<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">18</span></a>&#44; superior a la potencial v&#237;a sexual&#44; tambi&#233;n en personas sexualmente activas&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">La realizaci&#243;n de sexo transaccional no se relacion&#243; directamente con la presencia de pruebas positivas a SARS-CoV-2&#44; pero s&#237; con el n&#250;mero de parejas sexuales y el uso de mascarillas no filtrantes&#44; que ten&#237;an un precio elevado durante la realizaci&#243;n del estudio&#44; por lo que coincidimos con otros autores en considerar a las personas que ejercen la prostituci&#243;n como poblaci&#243;n de riesgo de coronavirus<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Durante el per&#237;odo estudiado se dieron un total de 178 diagn&#243;sticos de ITS&#44; algunas de las cuales ocurrieron de forma concomitante en la misma persona&#46; Ello va en l&#237;nea con el incremento global de ITS que se est&#225;n dando en nuestro pa&#237;s<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">19</span></a> y con el retorno a niveles de incidencia prepand&#233;micos<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; Aunque otro estudio relacion&#243; el aumento del n&#250;mero de casos de infecci&#243;n por SARS-CoV-2 en un hospital terciario valenciano con la disminuci&#243;n de la incidencia de ITS<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">22</span></a>&#44; la aproximaci&#243;n realizada en este trabajo no permite confirmar dicha relaci&#243;n&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">El estudio tiene varias fortalezas&#44; como el tama&#241;o muestral adecuado para dar respuesta al primer objetivo del art&#237;culo&#44; la consistencia en la recogida de datos por m&#233;dicos dermat&#243;logos subespecializados en venereolog&#237;a y la diversidad demogr&#225;fica de la poblaci&#243;n atendida&#46; Como limitaci&#243;n principal est&#225; la imposibilidad de separar completamente variables sociales en que puede haber confusi&#243;n y&#44; por tanto&#44; distinguir el impacto de cada una&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="par0135" class="elsevierStylePara elsevierViewall">La poblaci&#243;n sexualmente activa ha tenido pruebas positivas a SARS-CoV-2 con m&#225;s frecuencia que la poblaci&#243;n general&#46; A tenor de los datos&#44; la principal v&#237;a de contagio en este grupo es la respiratoria&#44; por lo que la transmisi&#243;n sexual parece muy limitada y probablemente relacionada con la proximidad que implican las relaciones sexuales&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicto de intereses</span><p id="par0140" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses relacionado con el contenido del presente art&#237;culo&#46;</p></span></span>"
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          "identificador" => "xpalclavsec1661924"
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            0 => "SARS-CoV-2"
            1 => "Pruebas de COVID-19"
            2 => "Enfermedades de transmisi&#243;n sexual"
            3 => "Transmisi&#243;n de enfermedades infecciosas"
            4 => "Venereolog&#237;a"
            5 => "Epidemiolog&#237;a"
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            0 => "SARS-CoV-2"
            1 => "COVID-19 tests"
            2 => "Sexually transmitted infections"
            3 => "Infectious disease transmission"
            4 => "Venereology"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Antecedentes y objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El SARS-CoV-2 se transmite con m&#225;s facilidad por cercan&#237;a f&#237;sica&#44; inherente a las relaciones sexuales&#44; lo que ha hecho plantearse que pueda haber una mayor incidencia de COVID-19 en personas con infecciones ven&#233;reas o de transmisi&#243;n sexual &#40;ITS&#41; o en riesgo de adquirirlas&#46; Por este motivo&#44; buscamos estimar la seroprevalencia de anticuerpos frente a SARS-CoV-2 en personas que acuden a una consulta monogr&#225;fica de ITS&#44; comparar dicha seroprevalencia con la estimada en nuestra regi&#243;n y estudiar los factores asociados&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material y m&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional transversal que incluye a pacientes mayores de 18 a&#241;os a&#250;n no vacunados atendidos en una consulta monogr&#225;fica municipal de ITS para estudio o cribado&#44; incluidos de forma consecutiva de marzo a abril de 2021&#46; Se realiz&#243; test serol&#243;gico r&#225;pido para SARS-CoV-2 y se recogieron variables demogr&#225;ficas&#44; sociales y sexuales&#44; diagn&#243;sticos de ITS y antecedentes de s&#237;ntomas compatibles con infecci&#243;n por SARS-CoV-2&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 512 pacientes&#44; el 37&#37; mujeres&#46; Tuvieron alguna prueba positiva a SARS-CoV-2 124 pacientes &#40;24&#44;2&#37;&#41;&#46; Se relacionaron con un resultado positivo&#58; el uso de mascarillas tipo FFP2 &#40;OR 0&#44;50&#41; y el n&#250;mero de parejas sexuales superior a la mediana &#40;OR 1&#44;80&#41;&#46; El uso de mascarillas FFP2 no se distribuy&#243; de manera aleatoria en la muestra&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La poblaci&#243;n sexualmente activa ha tenido pruebas positivas a SARS-CoV-2 con m&#225;s frecuencia que la poblaci&#243;n general&#46; La principal v&#237;a de contagio en este grupo parece ser la v&#237;a respiratoria&#44; por lo que la transmisi&#243;n sexual es probablemente limitada y est&#225; relacionada con la proximidad que implican las relaciones sexuales&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Antecedentes y objetivo"
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          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material y m&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusiones"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background and objective</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">SARS-CoV-2 is more easily spread by close contact&#44; which is inherent to sexual intercourse&#46; People with&#44; or at risk for&#44; sexually transmitted infections &#40;STIs&#41; may therefore have higher rates of COVID-19&#46; The aim of this study was to estimate SARS-CoV-2 antibody seroprevalence in people seen at a dedicated STI clinic&#44; compare our findings to the estimated seroprevalence in the local general population&#44; and study factors associated with SARS-CoV-2 infection in this setting&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Material and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional observational study including consecutive patients older than 18 years of age who had not yet been vaccinated against COVID-19 and who underwent examination or screening at a dedicated municipal STI clinic in March and April 2021&#46; We ordered rapid SARS-CoV-2 serology and collected information on demographic&#44; social&#44; and sexual variables&#44; STI diagnoses&#44; and history of symptoms compatible with SARS-CoV-2 infection&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We studied 512 patients &#40;37&#37; women&#41;&#46; Fourteen &#40;24&#46;2&#37;&#41; had a positive SARS-CoV-2 test&#46; Variables associated with positivity were use of FFP2 masks &#40;odds ratio 0&#46;50&#41; and a higher-than-average number of sexual partners &#40;odds ratio 1&#46;80&#41;&#46; Use of FFP2 masks was not randomly distributed in this sample&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Sexually active members of the population in this study had a higher incidence of SARS-CoV-2 infection than the general population&#46; The main route of infection in this group appears to be respiratory&#44; linked to close contact during sexual encounters&#59; sexual transmission of the virus is probably limited&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Background and objective"
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          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Material and methods"
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          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Conclusions"
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        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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          0 => array:4 [
            "imagen" => "gr1.jpeg"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Diagrama de flujo de inclusi&#243;n de pacientes&#46;</p>"
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      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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            "imagen" => "gr2.jpeg"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">C&#225;lculo mediante suavizado de gr&#225;fica de dispersi&#243;n ponderada localmente &#40;<span class="elsevierStyleItalic">locally weighted scatterplot smoothing&#44;</span> LOWESS&#41; de la probabilidad de obtener un resultado positivo de pruebas de SARS-CoV-2 respecto del n&#250;mero de parejas sexuales y el tipo de mascarilla utilizado&#46; La l&#237;nea vertical representa el percentil 75 &#40;8 parejas sexuales&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; RIC&#58; rango intercuart&#237;lico&#46;</p>"
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                  \t\t\t\t">32&#44;77 &#40;9&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">47 &#40;37&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Orientaci&#243;n sexual &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">196 &#40;50&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">238 &#40;46&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">177 &#40;45&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">61 &#40;49&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bisexual&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#46;&#176; de parejas sexuales en &#250;ltimos 3 meses&#44; mediana &#91;RIC&#93;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#46;&#176; de parejas sexuales en &#250;ltimo a&#241;o&#44; mediana &#91;RIC&#93;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">S&#237;ntomas compatibles con</span> COVID-19 <span class="elsevierStyleItalic">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>En algunas relaciones sexuales&#44; no durante toda su duraci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#46;&#176; de parejas sexuales en el &#250;ltimo a&#241;o&#44; mediana &#91;RIC&#93;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Antecedentes de prueba positiva a SARS-CoV-2 &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Todos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">388&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47 &#40;9&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva &#40;nuevo diagn&#243;stico&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva previamente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;10&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;10&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">13 &#40;10&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a de s&#237;filis &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;371&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Primaria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Secundaria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;3&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Latente precoz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;3&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;3&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;4&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Latente tard&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tratada &#40;cicatriz serol&#243;gica&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;16&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;16&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">360 &#40;77&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">274 &#40;77&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;77&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a del virus de hepatitis A &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;535&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">375 &#40;73&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">279 &#40;71&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;77&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Inmune&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;12&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48 &#40;12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;12&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;9&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Persona vacunada previamente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a del virus de hepatitis B &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;531&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">433 &#40;84&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">325 &#40;83&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108 &#40;87&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pasada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;1&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vacunada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a del virus de hepatitis C &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">103 &#40;20&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">82 &#40;21&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">21 &#40;17&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;396&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a del virus del herpes simple &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">496 &#40;96&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">376 &#40;96&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">120 &#40;96&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IgG positiva para el VHS tipo 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;1&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IgG positiva para el VHS tipo 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IgG positiva para los VHS tipo 1 y 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0 &#40;0&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;1&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">3 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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ARTÍCULO ORIGINAL
Infección por SARS-CoV-2 en pacientes con o en riesgo de infecciones venéreas: estudio de su incidencia y factores asociados en un centro monográfico de infecciones de transmisión sexual
SARS-CoV-2 infection in patients with or at risk for venereal infections: Incidence and associated factors in a sexual health clinic
A. Martin-Gorgojoa,
Corresponding author
alejandromartingorgojo@aedv.es

Autor para correspondencia.
, M. Menéndez-Orengab, A. Comunión-Artiedaa, R. Martín-Pozasa, P. Montero-Rivasc, F.-J. Bru-Gorraiza
a Servicio de Infecciones de Transmisión Sexual/Dermatología, Sección de Especialidades Médicas, Organismo Autónomo Madrid Salud, Ayuntamiento de Madrid, Madrid, España
b Centro de Salud La Ventilla, Servicio Madrileño de Salud, Instituto de Investigación Sanitaria del Hospital Universitario 12 de Octubre (IMAS12), Madrid, España
c Servicio de Farmacia, Organismo Autónomo Madrid Salud, Ayuntamiento de Madrid, Madrid, España
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pues&#44; que las personas con m&#250;ltiples contactos sexuales&#44; y especialmente aquellas involucradas en la prostituci&#243;n&#44; pueden tener aumentado el riesgo de COVID-19<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">10</span></a>&#44; tanto por el posible contagio sexual como por la cercan&#237;a f&#237;sica que implican las relaciones sexuales<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">11</span></a>&#46; La crisis econ&#243;mica que se ha producido relacionada con la epidemia de covid-19&#44; muy acusada en la ciudad de Madrid<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a>&#44; puede haber aumentado la vulnerabilidad de ciertos colectivos&#44; como el de las personas que ejercen la prostituci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">13&#44;14</span></a>&#44; al empujarlas a asumir riesgos de contagio &#40;de la propia infecci&#243;n por SARS-CoV-2 y de infecciones de transmisi&#243;n sexual&#44; ITS&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se han puesto en pr&#225;ctica distintas medidas preventivas durante la pandemia de COVID-19&#46; Antes de la aparici&#243;n de las vacunas muchas de ellas se centraron en la distancia social o las restricciones de movilidad&#46; Evaluar diferentes medidas de protecci&#243;n suele ser &#250;til en la fase de aprendizaje tras una crisis&#46; Los grupos de poblaci&#243;n sexualmente activa pueden tener un comportamiento particular respecto de las restricciones y medidas de prevenci&#243;n&#44; lo cual es relevante de cara a plantear medidas o mensajes focalizados&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Los objetivos del presente estudio son&#58; estimar la seroprevalencia de anticuerpos frente al virus SARS-CoV-2 en personas sexualmente activas atendidas en un servicio de ITS y analizar los factores sociales y preventivos relacionados con la infecci&#243;n por el SARS-CoV-2&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material y m&#233;todo</span><p id="par0030" class="elsevierStylePara elsevierViewall">Estudio observacional de corte transversal que incluy&#243; a todos aquellos pacientes mayores de 18 a&#241;os atendidos en la consulta monogr&#225;fica de ITS &#40;para estudio o cribado&#44; independientemente de la presencia o no de s&#237;ntomas de ITS&#41;&#44; no vacunados contra la COVID-19&#44; que firmaron un consentimiento para su inclusi&#243;n en el per&#237;odo del 10 de marzo al 21 de abril de 2021&#46; Haciendo uso del programa estad&#237;stico Epi-Info&#174; &#40;CDC&#44; Atlanta&#44; EE&#46;&#160;UU&#46;&#41;&#44; se calcul&#243; un tama&#241;o muestral necesario para la estimaci&#243;n de seroprevalencia de 500 pacientes&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Adem&#225;s de las exploraciones diagn&#243;sticas convencionales necesarias para el estudio o cribado de ITS&#44; se hizo una entrevista a los participantes sobre variables demogr&#225;ficas&#44; epidemiol&#243;gicas y conductuales&#44; y se realiz&#243; un test r&#225;pido de detecci&#243;n cualitativa de anticuerpos IgG e IgM frente al virus SARS-CoV-2 de Joysbio Technology&#174; &#40;Tianjin&#44; China&#44; lote 2020033006&#44; con 92&#44;4&#37; de sensibilidad y 94&#44;4&#37; de especificidad seg&#250;n los estudios remitidos en el momento de su adquisici&#243;n&#41; mediante la obtenci&#243;n de sangre capilar por digitopunci&#243;n&#46; En caso de darse un resultado que generase sospecha de infecci&#243;n activa por SARS-CoV-2&#44; se realiz&#243; test de detecci&#243;n de ant&#237;genos&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">El probable antecedente de infecci&#243;n por SARS-CoV-2 se defini&#243; bas&#225;ndose en la reactividad de la prueba serol&#243;gica r&#225;pida o en el antecedente de pruebas positivas para SARS-CoV-2 previas dentro del marco temporal pand&#233;mico&#46; A efectos de an&#225;lisis adicionales&#44; se defini&#243; a&#241;adiendo&#44; a los 2<span class="elsevierStyleHsp" style=""></span>criterios anteriores&#44; la presencia de s&#237;ntomas compatibles con COVID-19&#46; Aparte de las variables demogr&#225;ficas&#44; como el pa&#237;s de procedencia&#44; edad y sexo biol&#243;gico&#44; se recogieron variables sobre comportamientos como la orientaci&#243;n sexual&#44; el n&#250;mero de parejas sexuales&#44; la realizaci&#243;n de sexo transaccional&#44; consumo de alcohol&#44; pr&#225;ctica de <span class="elsevierStyleItalic">chemsex</span><a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">15</span></a>&#44; el uso de mascarilla durante las relaciones sexuales y el tipo de mascarilla utilizada habitualmente&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El cuaderno de recogida de datos en papel fue recodificado en una hoja de c&#225;lculo anonimizada para la gesti&#243;n de datos&#46; El estudio fue aprobado por el Comit&#233; de &#201;tica de la Investigaci&#243;n con Medicamentos del Hospital Universitario de la Princesa &#40;n&#250;mero de registro 4401&#44; c&#243;digo COVID19&#44; decisi&#243;n favorable de fecha 25-02-21&#44; acta CEIm 04&#47;21&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico se realiz&#243; con el programa R versi&#243;n 4&#46;1&#46;2&#46; Las variables categ&#243;ricas se expresaron como frecuencias&#44; la edad se describi&#243; con la media y desviaci&#243;n est&#225;ndar y el n&#250;mero de parejas sexuales a trav&#233;s de la mediana y el rango intercuart&#237;lico&#46; Para los contrastes de hip&#243;tesis en variables categ&#243;ricas se emple&#243; el test &#967;<span class="elsevierStyleSup">2</span>&#44; para la edad la t de Student y para el n&#250;mero de parejas sexuales el test de Wilcoxon-Mann-Whitney&#46; Se ajustaron 2<span class="elsevierStyleHsp" style=""></span>modelos de regresi&#243;n log&#237;stica binaria para la infecci&#243;n por SARS-CoV-2&#58; el principal&#44; utilizando como variable dependiente la seropositividad en prueba r&#225;pida o pruebas positivas previas&#44; y otro&#44; utilizando como variable dependiente la presencia de s&#237;ntomas compatibles&#46; En algunas trabajadoras sexuales no se pudo recoger el n&#250;mero de parejas sexuales&#44; por lo que se imputaron los valores perdidos con la mediana del grupo&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">Durante el per&#237;odo referido se realizaron 1&#46;018 visitas en consulta m&#233;dica&#44; correspondientes a 734 pacientes&#44; de los cuales 512 aceptaron ser incluidos en el estudio&#46; La <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> muestra el diagrama de flujo de inclusi&#243;n de pacientes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Un total de 124 pacientes &#40;24&#44;2&#37;&#41; tuvieron un resultado positivo en la prueba r&#225;pida serol&#243;gica o antecedentes de pruebas positivas de SARS-CoV-2 en el a&#241;o anterior&#46; Sumados aquellos que tuvieron s&#237;ntomas espec&#237;ficos de COVID-19 que no se pudieron hacer pruebas&#44; el n&#250;mero se elevaba a 208 pacientes &#40;40&#44;7&#37;&#41;&#46; Las pruebas serol&#243;gicas r&#225;pidas fueron reactivas en 24 pacientes&#44; 23 con IgG positiva y una con IgM positiva y prueba r&#225;pida de ant&#237;geno negativa&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se muestran las caracter&#237;sticas de los participantes y sus pr&#225;cticas de modo global y estratificados seg&#250;n de la presencia de serolog&#237;a positiva para coronavirus&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">En el an&#225;lisis bivariado se relacionaron con la serolog&#237;a positiva el uso de mascarillas distintas a las FFP2 y el n&#250;mero de parejas sexuales&#46; El tipo de mascarilla utilizada no se distribuy&#243; de modo aleatorio en la muestra&#58; las mascarillas FFP2 o asimilables fueron menos utilizadas por personas no europeas y personas que ejerc&#237;an la prostituci&#243;n&#46; La media de edad fue&#44; adem&#225;s&#44; ligeramente mayor en las personas que usaron mascarillas FFP2 o asimilables&#46; No encontramos relaci&#243;n entre el tipo de mascarilla utilizada y las pr&#225;cticas de su uso &#40;por ejemplo&#44; usarlas solo para evitar multas&#41;&#44; ni con su uso durante las relaciones sexuales &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Un subgrupo particular del estudio fue el de las 71 personas que ejerc&#237;an la prostituci&#243;n&#46; De ellas&#44; el 80&#37; eran mujeres cisg&#233;nero&#44; el 11&#37; hombres cisg&#233;nero y el 8&#44;5&#37; mujeres transg&#233;nero&#46; El 94&#44;4&#37; eran de origen no europeo y el 5&#44;6&#37; de origen europeo&#46; Solo el 11&#44;3&#37; us&#243; mascarillas tipo FFP2 o asimilables&#46; El 19&#44;7&#37; declar&#243; utilizar la mascarilla para evitar sanciones&#44; de forma similar al resto de la muestra&#46; Su mediana de parejas sexuales en los &#250;ltimos 3 meses fue de 80&#44; y en el &#250;ltimo a&#241;o 270&#44; claramente superior al resto de la muestra&#46; Hubo personas que disminuyeron o interrumpieron la prostituci&#243;n durante la pandemia&#58; 9 personas tuvieron 10 o menos parejas en los 3 meses previos al estudio&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Durante la atenci&#243;n a los pacientes se diagnosticaron diferentes infecciones de transmisi&#243;n sexual&#44; que se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46; Ninguna de ellas se identific&#243; con mayor frecuencia entre los pacientes con pruebas positivas para SARS-CoV-2&#46; El 10&#37; ten&#237;a infecci&#243;n por VIH conocida previamente y solo un paciente fue diagnosticado de VIH durante el estudio&#46; En el 6&#37; se identific&#243; s&#237;filis que requiri&#243; tratamiento&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">El n&#250;mero de parejas sexuales no sigui&#243; una distribuci&#243;n normal ni pudo asimilarse a la normalidad mediante logaritmos&#44; por lo que se categoriz&#243; seg&#250;n la mediana &#40;2 parejas sexuales en los &#250;ltimos 3 meses&#41;&#46; En el an&#225;lisis multivariante tener m&#225;s de la mediana de parejas sexuales se relacion&#243; con un resultado positivo para SARS-CoV-2 con una <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; de 1&#44;80 &#40;intervalo de confianza del 95&#37; &#91;IC&#160;95&#37;&#93;&#58; 1&#44;13-2&#44;88&#41; respecto de los pacientes que tuvieron la mediana o menos parejas&#46; El uso de mascarillas FFP2 fue protector&#44; con una OR de 0&#44;50 &#40;IC&#160;95&#37;&#58; 0&#44;28-0&#44;89&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Se relacionaron con la positividad o la presencia de s&#237;ntomas compatibles &#40;casos probables&#41; el n&#250;mero de parejas sexuales en los &#250;ltimos 3 meses&#44; con OR 1&#44;99 &#40;IC&#160;95&#37;&#58; 1&#44;32-3&#44;01&#41; y las mascarillas FFP2&#44; con OR 0&#44;49 &#40;IC&#160;95&#37;&#58; 0&#44;31-0&#44;79&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> se muestra el c&#225;lculo mediante suavizado de gr&#225;fica de dispersi&#243;n ponderada localmente &#40;<span class="elsevierStyleItalic">Locally weighted scatterplot smoothing</span>&#44; LOWESS&#41; de la probabilidad de obtener un resultado positivo de pruebas de SARS-CoV-2 respecto del n&#250;mero de parejas sexuales y el tipo de mascarilla utilizado&#46; La l&#237;nea vertical representa el percentil 75 &#40;8 parejas sexuales&#41;&#44; la estimaci&#243;n no es valorable en la cola de la distribuci&#243;n&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">La seroprevalencia global estimada de SARS-CoV-2 entre las personas con ITS o en riesgo de ITS atendidas en nuestro servicio monogr&#225;fico municipal es elevada &#40;24&#44;2&#37; en marzo-abril de 2021&#41;&#44; mayor que la estimada en el estudio m&#225;s cercano en el tiempo tanto en la Comunidad de Madrid &#40;18&#44;6&#37;&#59; IC&#160;95&#37;&#58; 16&#44;7-20&#44;6&#41;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">16</span></a> como en Espa&#241;a &#40;9&#44;9&#37;&#59; IC&#160;95&#37;&#58; 9&#44;4-10&#44;4&#41;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">17</span></a>&#46; Las caracter&#237;sticas que se relacionaron con la presencia de pruebas positivas fueron el uso de mascarillas que no fueran FFP2 y el mayor n&#250;mero de parejas sexuales&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">El uso de mascarillas sin filtro &#40;esto es&#44; no FFP2 o asimilables&#41; duplic&#243; el riesgo de contagio&#44; mientras que el n&#250;mero de parejas sexuales mayor a la mediana aument&#243; el riesgo un 80&#37;&#46; El uso de mascarillas FFP2 fue diferente en los distintos colectivos de la muestra&#58; fue llamativamente menos frecuente en un colectivo vulnerable como el de las personas que realizan sexo transaccional&#44; la mayor&#237;a de las cuales son no europeas&#46; No se relacion&#243; ninguna ITS con la presencia de pruebas positivas a SARS-CoV-2&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">En la estimaci&#243;n de la probabilidad de contagio mediante LOWESS facetada por parejas sexuales y uso de mascarillas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; se observa que el grupo de personas que usaron mascarillas FFP2 y no ten&#237;an parejas sexuales o ten&#237;an muy pocas presentaron un riesgo de contagio bajo&#44; a diferencia de las que utilizaron mascarillas no FFP2&#44; en que el riesgo era superior al 25&#37; incluso en personas sin parejas sexuales&#46; El riesgo aumenta en las personas que utilizan mascarillas FFP2 cuando hay m&#225;s parejas sexuales que la mediana&#46; Al interpretar esta gr&#225;fica debe tenerse en cuenta que el n&#250;mero de parejas sexuales es una variable con una cola a la derecha extraordinariamente larga&#44; con una cantidad peque&#241;a de personas que tiene un n&#250;mero alto de parejas sexuales&#58; en esta &#225;rea&#44; las estimaciones de la probabilidad de contagio son inestables y la informaci&#243;n es m&#225;s fiable en el &#225;rea izquierda del gr&#225;fico&#44; donde est&#225; la mayor&#237;a de los pacientes&#46; Sin embargo&#44; incluso en los pacientes con gran n&#250;mero de parejas sexuales no se observa un claro impacto en la estimaci&#243;n de la probabilidad de contagio&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En conjunto&#44; estas observaciones reafirman la importancia de la v&#237;a respiratoria para el contagio del SARS-CoV-2<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">1</span></a>&#44; dada la efectividad de las mascarillas faciales con filtro en su prevenci&#243;n<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">18</span></a>&#44; superior a la potencial v&#237;a sexual&#44; tambi&#233;n en personas sexualmente activas&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">La realizaci&#243;n de sexo transaccional no se relacion&#243; directamente con la presencia de pruebas positivas a SARS-CoV-2&#44; pero s&#237; con el n&#250;mero de parejas sexuales y el uso de mascarillas no filtrantes&#44; que ten&#237;an un precio elevado durante la realizaci&#243;n del estudio&#44; por lo que coincidimos con otros autores en considerar a las personas que ejercen la prostituci&#243;n como poblaci&#243;n de riesgo de coronavirus<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Durante el per&#237;odo estudiado se dieron un total de 178 diagn&#243;sticos de ITS&#44; algunas de las cuales ocurrieron de forma concomitante en la misma persona&#46; Ello va en l&#237;nea con el incremento global de ITS que se est&#225;n dando en nuestro pa&#237;s<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">19</span></a> y con el retorno a niveles de incidencia prepand&#233;micos<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; Aunque otro estudio relacion&#243; el aumento del n&#250;mero de casos de infecci&#243;n por SARS-CoV-2 en un hospital terciario valenciano con la disminuci&#243;n de la incidencia de ITS<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">22</span></a>&#44; la aproximaci&#243;n realizada en este trabajo no permite confirmar dicha relaci&#243;n&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">El estudio tiene varias fortalezas&#44; como el tama&#241;o muestral adecuado para dar respuesta al primer objetivo del art&#237;culo&#44; la consistencia en la recogida de datos por m&#233;dicos dermat&#243;logos subespecializados en venereolog&#237;a y la diversidad demogr&#225;fica de la poblaci&#243;n atendida&#46; Como limitaci&#243;n principal est&#225; la imposibilidad de separar completamente variables sociales en que puede haber confusi&#243;n y&#44; por tanto&#44; distinguir el impacto de cada una&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="par0135" class="elsevierStylePara elsevierViewall">La poblaci&#243;n sexualmente activa ha tenido pruebas positivas a SARS-CoV-2 con m&#225;s frecuencia que la poblaci&#243;n general&#46; A tenor de los datos&#44; la principal v&#237;a de contagio en este grupo es la respiratoria&#44; por lo que la transmisi&#243;n sexual parece muy limitada y probablemente relacionada con la proximidad que implican las relaciones sexuales&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicto de intereses</span><p id="par0140" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses relacionado con el contenido del presente art&#237;culo&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Antecedentes y objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El SARS-CoV-2 se transmite con m&#225;s facilidad por cercan&#237;a f&#237;sica&#44; inherente a las relaciones sexuales&#44; lo que ha hecho plantearse que pueda haber una mayor incidencia de COVID-19 en personas con infecciones ven&#233;reas o de transmisi&#243;n sexual &#40;ITS&#41; o en riesgo de adquirirlas&#46; Por este motivo&#44; buscamos estimar la seroprevalencia de anticuerpos frente a SARS-CoV-2 en personas que acuden a una consulta monogr&#225;fica de ITS&#44; comparar dicha seroprevalencia con la estimada en nuestra regi&#243;n y estudiar los factores asociados&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material y m&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional transversal que incluye a pacientes mayores de 18 a&#241;os a&#250;n no vacunados atendidos en una consulta monogr&#225;fica municipal de ITS para estudio o cribado&#44; incluidos de forma consecutiva de marzo a abril de 2021&#46; Se realiz&#243; test serol&#243;gico r&#225;pido para SARS-CoV-2 y se recogieron variables demogr&#225;ficas&#44; sociales y sexuales&#44; diagn&#243;sticos de ITS y antecedentes de s&#237;ntomas compatibles con infecci&#243;n por SARS-CoV-2&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 512 pacientes&#44; el 37&#37; mujeres&#46; Tuvieron alguna prueba positiva a SARS-CoV-2 124 pacientes &#40;24&#44;2&#37;&#41;&#46; Se relacionaron con un resultado positivo&#58; el uso de mascarillas tipo FFP2 &#40;OR 0&#44;50&#41; y el n&#250;mero de parejas sexuales superior a la mediana &#40;OR 1&#44;80&#41;&#46; El uso de mascarillas FFP2 no se distribuy&#243; de manera aleatoria en la muestra&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La poblaci&#243;n sexualmente activa ha tenido pruebas positivas a SARS-CoV-2 con m&#225;s frecuencia que la poblaci&#243;n general&#46; La principal v&#237;a de contagio en este grupo parece ser la v&#237;a respiratoria&#44; por lo que la transmisi&#243;n sexual es probablemente limitada y est&#225; relacionada con la proximidad que implican las relaciones sexuales&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Antecedentes y objetivo"
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          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material y m&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusiones"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background and objective</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">SARS-CoV-2 is more easily spread by close contact&#44; which is inherent to sexual intercourse&#46; People with&#44; or at risk for&#44; sexually transmitted infections &#40;STIs&#41; may therefore have higher rates of COVID-19&#46; The aim of this study was to estimate SARS-CoV-2 antibody seroprevalence in people seen at a dedicated STI clinic&#44; compare our findings to the estimated seroprevalence in the local general population&#44; and study factors associated with SARS-CoV-2 infection in this setting&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Material and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional observational study including consecutive patients older than 18 years of age who had not yet been vaccinated against COVID-19 and who underwent examination or screening at a dedicated municipal STI clinic in March and April 2021&#46; We ordered rapid SARS-CoV-2 serology and collected information on demographic&#44; social&#44; and sexual variables&#44; STI diagnoses&#44; and history of symptoms compatible with SARS-CoV-2 infection&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We studied 512 patients &#40;37&#37; women&#41;&#46; Fourteen &#40;24&#46;2&#37;&#41; had a positive SARS-CoV-2 test&#46; Variables associated with positivity were use of FFP2 masks &#40;odds ratio 0&#46;50&#41; and a higher-than-average number of sexual partners &#40;odds ratio 1&#46;80&#41;&#46; Use of FFP2 masks was not randomly distributed in this sample&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Sexually active members of the population in this study had a higher incidence of SARS-CoV-2 infection than the general population&#46; The main route of infection in this group appears to be respiratory&#44; linked to close contact during sexual encounters&#59; sexual transmission of the virus is probably limited&#46;</p></span>"
        "secciones" => array:4 [
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            "titulo" => "Background and objective"
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          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Material and methods"
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          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Conclusions"
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        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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            "imagen" => "gr1.jpeg"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Diagrama de flujo de inclusi&#243;n de pacientes&#46;</p>"
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      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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            "imagen" => "gr2.jpeg"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">C&#225;lculo mediante suavizado de gr&#225;fica de dispersi&#243;n ponderada localmente &#40;<span class="elsevierStyleItalic">locally weighted scatterplot smoothing&#44;</span> LOWESS&#41; de la probabilidad de obtener un resultado positivo de pruebas de SARS-CoV-2 respecto del n&#250;mero de parejas sexuales y el tipo de mascarilla utilizado&#46; La l&#237;nea vertical representa el percentil 75 &#40;8 parejas sexuales&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; RIC&#58; rango intercuart&#237;lico&#46;</p>"
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                  \t\t\t\t">388&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32&#44;77 &#40;9&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47 &#40;37&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Orientaci&#243;n sexual &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">196 &#40;50&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">238 &#40;46&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">177 &#40;45&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61 &#40;49&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bisexual&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;4&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15 &#40;3&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#46;&#176; de parejas sexuales en &#250;ltimos 3 meses&#44; mediana &#91;RIC&#93;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#46;&#176; de parejas sexuales en &#250;ltimo a&#241;o&#44; mediana &#91;RIC&#93;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">149 &#40;37&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">41 &#40;34&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;619&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Origen europeo &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Orientaci&#243;n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;391&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heterosexual&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">253 &#40;49&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">52 &#40;44&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Homosexual&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">238 &#40;46&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">178 &#40;45&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">60 &#40;50&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Ejercicio de prostituci&#243;n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Uso de mascarilla b&#225;sicamente para evitar sanciones &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">82 &#40;20&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Mascarilla durante las relaciones sexuales &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nunca&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva &#40;nuevo diagn&#243;stico&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positiva previamente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;10&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a de s&#237;filis &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;371&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Primaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;0&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Secundaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;3&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Latente precoz&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;3&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;3&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;4&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Latente tard&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tratada &#40;cicatriz serol&#243;gica&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;16&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;16&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">360 &#40;77&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">274 &#40;77&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">86 &#40;77&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a del virus de hepatitis A &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;535&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">375 &#40;73&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">279 &#40;71&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;77&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Inmune&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;12&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48 &#40;12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;12&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;9&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Persona vacunada previamente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a del virus de hepatitis B &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;531&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">433 &#40;84&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">325 &#40;83&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108 &#40;87&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pasada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vacunada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Serolog&#237;a del virus de hepatitis C &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">103 &#40;20&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">21 &#40;17&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;396&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;85&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No realizada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IgG positiva para el VHS tipo 2&nbsp;\t\t\t\t\t\t\n
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ISSN: 00017310
Original language: Spanish
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