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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">El art&#237;culo sobre pitiriasis rosada &#40;PR&#41; en un paciente pedi&#225;trico de COVID-19 &#40;enfermedad por coronavirus de 2019&#41; redactado por &#214;nc&#252; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> y recientemente publicado en su revista nos ha impulsado a realizar algunas observaciones y a describir nuestra experiencia&#46; Los autores establecen ciertamente que la PR est&#225; asociada a la reactivaci&#243;n sist&#233;mica de herpesvirus humano &#40;HHV&#41; 6 y&#47;o 7<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#44; pero la patogenia de la PR incluye tambi&#233;n autoinmunidad&#44; factores psicog&#233;nicos&#44; vacunas y f&#225;rmacos&#44; sin realizar distinci&#243;n alguna entre PR y erupciones de tipo PR<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&#46; De hecho&#44; aunque es cierto que todos estos factores pueden causar dicha reactivaci&#243;n&#44; y causar por tanto de manera indirecta la aparici&#243;n de PR&#44; las vacunas y los f&#225;rmacos est&#225;n realmente m&#225;s implicados en causar erupciones de tipo PR<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; Estamos plenamente de acuerdo con los autores en cuanto a que durante la pandemia de COVID-19 el diagn&#243;stico de PR se ha convertido en algo m&#225;s habitual<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> y que tras la introducci&#243;n de las vacunas frente a la COVID-19 se ha incrementado tambi&#233;n el diagn&#243;stico de erupciones de tipo PR<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Al paciente descrito por &#214;nc&#252; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> se le diagnostic&#243; PR aunque&#44; lamentablemente&#44; no se han reportado ciertas caracter&#237;sticas espec&#237;ficas de la enfermedad&#46; Los autores no han mencionado la posible presencia de placa her&#225;ldica y de lesiones orofar&#237;ngeas<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>&#44; siendo estas &#250;ltimas comunes en ni&#241;os<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#46; Tampoco comentan s&#237;ntomas sist&#233;micos&#47;locales que puedan justificar el tratamiento con pomada de betametasona valerato&#44; urea al 10&#37; y cetirizina&#46; De hecho&#44; hasta la fecha no se ha recomendado tratamiento en funci&#243;n de la medicina basada en la evidencia&#44; ya que la PR es una enfermedad exantem&#225;tica autolimitada que solo precisa tranquilidad y reposo<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46; El tratamiento antiviral con dosis bajas de aciclovir deber&#225; considerarse &#250;nicamente en casos de PR extensa&#44; recidivante o persistente con s&#237;ntomas sist&#233;micos asociados&#44; para acortar el curso de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#59; adem&#225;s&#44; la PR en el embarazo puede ocasionar una posible infecci&#243;n fetal intrauterina por HHV-6&#47;7 con parto prematuro y muerte fetal&#46; As&#237;&#44; la aparici&#243;n de PR con anterioridad a la semana<span class="elsevierStyleHsp" style=""></span>15&#44; la presencia de enantema y el compromiso &#62;<span class="elsevierStyleHsp" style=""></span>50&#37; del cuerpo constituyen factores de riesgo en el embarazo de resultado negativo&#44; consider&#225;ndose adecuada la terapia antiviral en tales casos<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Lamentablemente&#44; al paciente descrito por &#214;nc&#252; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> no se le realiz&#243; serolog&#237;a ni reacci&#243;n en cadena de la polimerasa &#40;PCR&#41; s&#233;rica para ADN de HHV-6&#47;7 ni ARN de SARS-CoV-2&#46; Dichas investigaciones habr&#237;an sido &#250;tiles para esclarecer el posible papel de SARS-CoV-2 en la patogenia de la PR asociada a COVID-19&#46; De hecho&#44; SARS-CoV-2 puede jugar un papel como agente transactivador&#44; desencadenando la reactivaci&#243;n de HHV-6 y&#47;o HHV-7 y causando&#44; de manera indirecta&#44; la aparici&#243;n de PR<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#44; seg&#250;n la hip&#243;tesis de los autores<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a>&#46; Por tanto&#44; recomendamos vivamente la realizaci&#243;n de dichas pruebas en pacientes con desarrollo de PR en el contexto de COVID-19&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La histopatolog&#237;a de la biopsia cut&#225;nea de la lesi&#243;n &#40;que deber&#237;a numerarse en el art&#237;culo como figura 2&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> muestra realmente extravasaci&#243;n de hemat&#237;es en la dermis&#44; lo cual es bastante t&#237;pico en la PR&#44; descrita incorrectamente por los autores como &#171;infiltraci&#243;n eritroc&#237;tica perivascular&#187;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a>&#46; Por &#250;ltimo&#44; la definici&#243;n de &#171;infecci&#243;n por COVID-19&#187; deber&#237;a sustituirse m&#225;s adecuadamente por &#171;infecci&#243;n por SARS-CoV-2&#187;&#46;</p></span>"
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Carta Al Director
Comentario sobre «Pitiriasis rosada en un paciente pediátrico de COVID-19»
Comment on «Pityriasis rosea in a COVID-19 Pediatric Patient»
G. Ciccaresea,
Corresponding author
giuliaciccarese@libero.it

Autor para correspondencia.
, F. Dragoa,b, A. Parodia,b
a Dermatology Unit, Ospedale Policlinico San Martino, Génova, Italia
b DI.S.Sal., Section of Dermatology, University of Genoa, Genova, Italia
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">El art&#237;culo sobre pitiriasis rosada &#40;PR&#41; en un paciente pedi&#225;trico de COVID-19 &#40;enfermedad por coronavirus de 2019&#41; redactado por &#214;nc&#252; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> y recientemente publicado en su revista nos ha impulsado a realizar algunas observaciones y a describir nuestra experiencia&#46; Los autores establecen ciertamente que la PR est&#225; asociada a la reactivaci&#243;n sist&#233;mica de herpesvirus humano &#40;HHV&#41; 6 y&#47;o 7<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#44; pero la patogenia de la PR incluye tambi&#233;n autoinmunidad&#44; factores psicog&#233;nicos&#44; vacunas y f&#225;rmacos&#44; sin realizar distinci&#243;n alguna entre PR y erupciones de tipo PR<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&#46; De hecho&#44; aunque es cierto que todos estos factores pueden causar dicha reactivaci&#243;n&#44; y causar por tanto de manera indirecta la aparici&#243;n de PR&#44; las vacunas y los f&#225;rmacos est&#225;n realmente m&#225;s implicados en causar erupciones de tipo PR<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; Estamos plenamente de acuerdo con los autores en cuanto a que durante la pandemia de COVID-19 el diagn&#243;stico de PR se ha convertido en algo m&#225;s habitual<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> y que tras la introducci&#243;n de las vacunas frente a la COVID-19 se ha incrementado tambi&#233;n el diagn&#243;stico de erupciones de tipo PR<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Al paciente descrito por &#214;nc&#252; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> se le diagnostic&#243; PR aunque&#44; lamentablemente&#44; no se han reportado ciertas caracter&#237;sticas espec&#237;ficas de la enfermedad&#46; Los autores no han mencionado la posible presencia de placa her&#225;ldica y de lesiones orofar&#237;ngeas<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>&#44; siendo estas &#250;ltimas comunes en ni&#241;os<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#46; Tampoco comentan s&#237;ntomas sist&#233;micos&#47;locales que puedan justificar el tratamiento con pomada de betametasona valerato&#44; urea al 10&#37; y cetirizina&#46; De hecho&#44; hasta la fecha no se ha recomendado tratamiento en funci&#243;n de la medicina basada en la evidencia&#44; ya que la PR es una enfermedad exantem&#225;tica autolimitada que solo precisa tranquilidad y reposo<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46; El tratamiento antiviral con dosis bajas de aciclovir deber&#225; considerarse &#250;nicamente en casos de PR extensa&#44; recidivante o persistente con s&#237;ntomas sist&#233;micos asociados&#44; para acortar el curso de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#59; adem&#225;s&#44; la PR en el embarazo puede ocasionar una posible infecci&#243;n fetal intrauterina por HHV-6&#47;7 con parto prematuro y muerte fetal&#46; As&#237;&#44; la aparici&#243;n de PR con anterioridad a la semana<span class="elsevierStyleHsp" style=""></span>15&#44; la presencia de enantema y el compromiso &#62;<span class="elsevierStyleHsp" style=""></span>50&#37; del cuerpo constituyen factores de riesgo en el embarazo de resultado negativo&#44; consider&#225;ndose adecuada la terapia antiviral en tales casos<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Lamentablemente&#44; al paciente descrito por &#214;nc&#252; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> no se le realiz&#243; serolog&#237;a ni reacci&#243;n en cadena de la polimerasa &#40;PCR&#41; s&#233;rica para ADN de HHV-6&#47;7 ni ARN de SARS-CoV-2&#46; Dichas investigaciones habr&#237;an sido &#250;tiles para esclarecer el posible papel de SARS-CoV-2 en la patogenia de la PR asociada a COVID-19&#46; De hecho&#44; SARS-CoV-2 puede jugar un papel como agente transactivador&#44; desencadenando la reactivaci&#243;n de HHV-6 y&#47;o HHV-7 y causando&#44; de manera indirecta&#44; la aparici&#243;n de PR<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#44; seg&#250;n la hip&#243;tesis de los autores<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a>&#46; Por tanto&#44; recomendamos vivamente la realizaci&#243;n de dichas pruebas en pacientes con desarrollo de PR en el contexto de COVID-19&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La histopatolog&#237;a de la biopsia cut&#225;nea de la lesi&#243;n &#40;que deber&#237;a numerarse en el art&#237;culo como figura 2&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> muestra realmente extravasaci&#243;n de hemat&#237;es en la dermis&#44; lo cual es bastante t&#237;pico en la PR&#44; descrita incorrectamente por los autores como &#171;infiltraci&#243;n eritroc&#237;tica perivascular&#187;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a>&#46; Por &#250;ltimo&#44; la definici&#243;n de &#171;infecci&#243;n por COVID-19&#187; deber&#237;a sustituirse m&#225;s adecuadamente por &#171;infecci&#243;n por SARS-CoV-2&#187;&#46;</p></span>"
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              "etiqueta" => "3"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pityriasis rosea and pityriasis rosea-like eruption&#58; Can they be distinguished&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Drago"
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                            2 => "A&#46; Rebora"
                            3 => "A&#46; Parodi"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "paginaFinal" => "865"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25182298"
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              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
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                      "titulo" => "Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions&#58; A review of the literature"
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                          "etal" => false
                          "autores" => array:4 [
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
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                        "volumen" => "30"
                        "paginaInicial" => "544"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25545307"
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                          "etal" => false
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                  "host" => array:1 [
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                        "fecha" => "2020"
                        "volumen" => "33"
                        "paginaInicial" => "e13730"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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              ]
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                    0 => array:2 [
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                          "etal" => true
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                      ]
                    ]
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                  "host" => array:1 [
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                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
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            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oropharyngeal lesions in pityriasis rosea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; Ciccarese"
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                            4 => "F&#46; Drago"
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                        ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2017.06.033"
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                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "77"
                        "paginaInicial" => "833"
                        "paginaFinal" => "837&#46;e4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28728872"
                            "web" => "Medline"
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                ]
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              "identificador" => "bib0090"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The efficacy of macrolides and acyclovir in pityriasis rosea"
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                            0 => "F&#46; Drago"
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                        "tituloSerie" => "Indian J Dermatol Venereol Leprol&#46;"
                        "fecha" => "2015"
                        "volumen" => "81"
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                    ]
                  ]
                ]
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                          "etal" => false
                          "autores" => array:5 [
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                ]
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Article information
ISSN: 00017310
Original language: Spanish
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