Experiencia clínica del uso de adalimumab en el manejo de la hidradenitis supurativa. Comparando las tasas de respuesta con la enfermedad de Crohn
Clinical experience of the use of adalimumab in the management of hidradenitis suppurativa. Comparison of response rates with Crohn disease
a Servicio de Dermatología, Hospital Punta de Europa, Algeciras, Cádiz, España
b Servicio de Gastroenterología, Hospital General Universitario Gregorio Marañón, Madrid, España
c Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, España
d Servicio de Dermatología, Hospital de Manises, Valencia, España
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"apellidos" => "Martorell" "email" => array:1 [ 0 => "antmarto@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Punta de Europa, Algeciras, Cádiz, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Gastroenterología, Hospital General Universitario Gregorio Marañón, Madrid, España" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, España" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de Manises, Valencia, España" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical experience of the use of adalimumab in the management of hidradenitis suppurativa. Comparison of response rates with Crohn disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec785662" "palabras" => array:7 [ 0 => "Hidradenitis supurativa" 1 => "Hidrosadenitis supurativa" 2 => "Acné inverso" 3 => "Enfermedad inflamatoria intestinal" 4 => "Enfermedad de Crohn" 5 => "Colitis ulcerosa" 6 => "Adalimumab" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec785661" "palabras" => array:7 [ 0 => "Hidradenitis suppurativa" 1 => "Hidrosadenitis suppurative" 2 => "Inverse acne" 3 => "Inflammatory bowel disease" 4 => "Crohn disease" 5 => "Ulcerative colitis" 6 => "Adalimumab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La reciente aprobación de adalimumab como el primer tratamiento con indicación para el manejo de la hidradenitis supurativa ha supuesto un antes y un después en el control de esta patología inflamatoria crónica. Dada la carga inflamatoria de esta enfermedad cutánea, en los últimos años se han comparado la hidradenitis supurativa y la enfermedad inflamatoria intestinal, en especial con la enfermedad de Crohn, hasta el punto de considerarse la enfermedad dermatológica como “la enfermedad de Crohn de la piel”. Estas 2 enfermedades inflamatorias crónicas presentan un grado de similitud lo suficientemente importante como para plantearse si la respuesta terapéutica sobre la base de su carga inflamatoria podría ser también comparable. En el presente trabajo se pretende analizar la eficacia de adalimumab en la hidradenitis supurativa frente a una patología realmente comparable, la enfermedad de Crohn, con el fin de valorar las tasas de respuesta terapéutica y establecer conclusiones con respecto al éxito terapéutico obtenido en esta invalidante enfermedad cutánea.</p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The recent approval of adalimumab as the first treatment to be approved for the management of hidradenitis suppurativa has represented a before and after in the control of this chronic inflammatory disease. Given the inflammatory burden of this cutaneous disease, in the last few years hidradenitis suppurativa has been compared with inflammatory bowel disease, particularly with Crohn disease, to the point of considering hidradenitis suppurativa as “Crohn disease of the skin”. These two chronic inflammatory diseases show sufficient similarities to consider whether treatment response based on the inflammatory load could also be similar. The present article aims to analyse the efficacy of adalimumab in hidradenitis suppurativa in comparison with a truly comparable disease, Crohn disease, with a view to evaluating therapeutic response rates and to drawing conclusions on the therapeutic success obtained in this disabling cutaneous disease.</p></span>" ] ] ] "idiomaDefecto" => "es" "url" => "/00017310/00000107000000S2/v1_201701100052/S000173101730008X/v1_201701100052/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/00017310/00000107000000S2/v1_201701100052/S000173101730008X/v1_201701100052/es/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101730008X?idApp=UINPBA000044" ]
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