Ustekinumab en situaciones especiales: embarazo, interrupciones temporales (vacunaciones, cirugía) y otros
Ustekinumab in special situations: pregnancy, temporal interruptions (vaccinations, surgery) and others
Servicio de Dermatología. Hospital Universitario 12 de Octubre. Madrid. España
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"apellidos" => "Bordas" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012700091?idApp=UINPBA000044" "url" => "/00017310/00000103000000S2/v1_201304241722/S0001731012700091/v1_201304241722/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0001731012700078" "issn" => "00017310" "doi" => "10.1016/S0001-7310(12)70007-8" "estado" => "S300" "fechaPublicacion" => "2012-10-01" "aid" => "70007" "copyright" => "Academia Española de Dermatología y Venereología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2012;103 Supl 2:39-44" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 962 "formatos" => array:3 [ "EPUB" => 1 "HTML" => 536 "PDF" => 425 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Ustekinumab. Neoplasias y otros aspectos de seguridad" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "39" "paginaFinal" => "44" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ustekinumab. Neoplasms and Other Safety Aspects" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Santos-Juanes, P. Coto, C. Galache" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Santos-Juanes" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Coto" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Galache" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012700078?idApp=UINPBA000044" "url" => "/00017310/00000103000000S2/v1_201304241722/S0001731012700078/v1_201304241722/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Ustekinumab en situaciones especiales: embarazo, interrupciones temporales (vacunaciones, cirugía) y otros" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "45" "paginaFinal" => "51" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Rivera, F. Vanaclocha" "autores" => array:2 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Rivera" "email" => array:1 [ 0 => "rriveradiaz@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Vanaclocha" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología. Hospital Universitario 12 de Octubre. Madrid. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ustekinumab in special situations: pregnancy, temporal interruptions (vaccinations, surgery) and others" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85098" "palabras" => array:5 [ 0 => "Ustekinumab" 1 => "Embarazo" 2 => "Vacunas" 3 => "Cirugía" 4 => "Infecciones oportunistas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85097" "palabras" => array:5 [ 0 => "Ustekinumab" 1 => "Pregnancy" 2 => "Vaccines" 3 => "Surgery" 4 => "Opportunistic infections" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La psoriasis es una enfermedad crónica que cursa en brotes. Algunos pacientes los sufren con tanta frecuencia que precisan un tratamiento continuo para su control. Es en muchos de estos pacientes donde empleamos las nuevas terapias biológicas como el ustekinumab, que nos permiten tratamientos prolongados evitando la toxicidad acumulada que tienen muchos de los tratamientos clásicos. Sin embargo, a lo largo del curso de estos tratamientos hay situaciones en las que sería deseable interrumpirlos o al menos sopesar adecuadamente con el paciente el riesgo-beneficio de mantenerlos.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En este capítulo, partiendo de un caso clínico, revisamos algunas de estas situaciones especiales como el embarazo, las interrupciones temporales por vacunaciones o cirugía y qué tenemos que hacer en caso de que nuestros pacientes en tratamiento con ustekinumab viajen al extranjero o procedan de zonas endémicas de determinados problemas infecciosos. Pretendemos facilitar la toma de decisiones ante estas situaciones especiales que se nos plantean a diario en la consulta.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Psoriasis is a chronic disease characterized by recurrent flares and in some patients the outbreaks occur so close together that continuous treatment is necessary. Newly developed biologic agents such as ustekinumab are often used in such cases because they offer the possibility of long-term treatment without the risk of cumulative toxicity associated with many traditional psoriasis therapies. There are, however, situations when biologic treatment might have to be interrupted. In such cases, it is important to discuss the issues with the patient and carefully weigh the benefits and risks of continuing or interrupting treatment.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In this chapter, we review a series of clinical cases and provide insights that will facilitate decision-making in routine clinical practice regarding the use of ustekinumab in special circumstances. The cases discussed include patients who become or wish to become pregnant, temporary interruptions due to vaccination or surgery, and patients who plan to travel to or come from a country where opportunistic infections are endemic.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 7 | 9 |
| 2024 October | 38 | 35 | 73 |
| 2024 September | 27 | 22 | 49 |
| 2024 August | 45 | 62 | 107 |
| 2024 July | 40 | 30 | 70 |
| 2024 June | 57 | 38 | 95 |
| 2024 May | 33 | 36 | 69 |
| 2024 April | 34 | 35 | 69 |
| 2024 March | 29 | 37 | 66 |
| 2024 February | 27 | 35 | 62 |
| 2024 January | 22 | 24 | 46 |
| 2023 December | 39 | 27 | 66 |
| 2023 November | 33 | 23 | 56 |
| 2023 October | 33 | 18 | 51 |
| 2023 September | 39 | 31 | 70 |
| 2023 August | 27 | 23 | 50 |
| 2023 July | 32 | 28 | 60 |
| 2023 June | 39 | 24 | 63 |
| 2023 May | 20 | 16 | 36 |
| 2023 April | 29 | 20 | 49 |
| 2023 March | 71 | 23 | 94 |
| 2023 February | 30 | 19 | 49 |
| 2023 January | 38 | 26 | 64 |
| 2022 December | 29 | 37 | 66 |
| 2022 November | 34 | 44 | 78 |
| 2022 October | 36 | 28 | 64 |
| 2022 September | 27 | 35 | 62 |
| 2022 August | 32 | 38 | 70 |
| 2022 July | 36 | 45 | 81 |
| 2022 June | 24 | 33 | 57 |
| 2022 May | 30 | 36 | 66 |
| 2022 April | 40 | 44 | 84 |
| 2022 March | 27 | 58 | 85 |
| 2022 February | 26 | 31 | 57 |
| 2022 January | 40 | 43 | 83 |
| 2021 December | 21 | 40 | 61 |
| 2021 November | 32 | 42 | 74 |
| 2021 October | 35 | 49 | 84 |
| 2021 September | 21 | 49 | 70 |
| 2021 August | 32 | 49 | 81 |
| 2021 July | 38 | 40 | 78 |
| 2021 June | 33 | 38 | 71 |
| 2021 May | 49 | 43 | 92 |
| 2021 April | 63 | 48 | 111 |
| 2021 March | 43 | 42 | 85 |
| 2021 February | 27 | 23 | 50 |
| 2021 January | 32 | 22 | 54 |
| 2020 December | 16 | 25 | 41 |
| 2020 November | 15 | 24 | 39 |
| 2020 October | 30 | 17 | 47 |
| 2020 September | 7 | 25 | 32 |
| 2020 August | 24 | 19 | 43 |
| 2020 July | 18 | 17 | 35 |
| 2020 June | 22 | 32 | 54 |
| 2020 May | 29 | 34 | 63 |
| 2020 April | 17 | 22 | 39 |
| 2020 March | 20 | 24 | 44 |
| 2020 February | 31 | 5 | 36 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 6 | 6 |
| 2019 November | 1 | 8 | 9 |
| 2019 October | 0 | 7 | 7 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 9 | 9 |
| 2019 July | 0 | 14 | 14 |
| 2019 June | 0 | 20 | 20 |
| 2019 May | 0 | 59 | 59 |
| 2019 April | 1 | 28 | 29 |
| 2019 March | 0 | 3 | 3 |
| 2019 February | 0 | 4 | 4 |
| 2019 January | 0 | 1 | 1 |
| 2018 December | 0 | 4 | 4 |
| 2018 November | 0 | 1 | 1 |
| 2018 October | 0 | 2 | 2 |
| 2018 September | 0 | 5 | 5 |
| 2018 August | 0 | 27 | 27 |
| 2018 July | 0 | 4 | 4 |
| 2018 June | 0 | 5 | 5 |
| 2018 May | 0 | 8 | 8 |
| 2018 April | 0 | 6 | 6 |
| 2018 March | 0 | 5 | 5 |
| 2018 February | 23 | 11 | 34 |
| 2018 January | 20 | 11 | 31 |
| 2017 December | 31 | 17 | 48 |
| 2017 November | 26 | 13 | 39 |
| 2017 October | 17 | 34 | 51 |
| 2017 September | 18 | 25 | 43 |
| 2017 August | 19 | 18 | 37 |
| 2017 July | 15 | 15 | 30 |
| 2017 June | 23 | 22 | 45 |
| 2017 May | 24 | 19 | 43 |
| 2017 April | 28 | 22 | 50 |
| 2017 March | 23 | 12 | 35 |
| 2017 February | 29 | 31 | 60 |
| 2017 January | 30 | 17 | 47 |
| 2016 December | 30 | 15 | 45 |
| 2016 November | 34 | 16 | 50 |
| 2016 October | 39 | 11 | 50 |
| 2016 September | 35 | 32 | 67 |
| 2016 August | 31 | 12 | 43 |
| 2016 July | 21 | 5 | 26 |
| 2016 June | 0 | 6 | 6 |
| 2016 May | 0 | 14 | 14 |
| 2016 April | 0 | 1 | 1 |
| 2016 March | 0 | 3 | 3 |
| 2016 February | 0 | 4 | 4 |
| 2016 January | 0 | 11 | 11 |
| 2015 December | 1 | 6 | 7 |
| 2015 November | 6 | 10 | 16 |
| 2015 October | 4 | 10 | 14 |
| 2015 September | 9 | 10 | 19 |
| 2015 August | 8 | 9 | 17 |
| 2015 July | 42 | 2 | 44 |
| 2015 June | 51 | 8 | 59 |
| 2015 May | 61 | 22 | 83 |
| 2015 April | 48 | 19 | 67 |
| 2015 March | 44 | 11 | 55 |
| 2015 February | 25 | 10 | 35 |
| 2015 January | 20 | 14 | 34 |
| 2014 December | 38 | 8 | 46 |
| 2014 November | 30 | 14 | 44 |
| 2014 October | 33 | 23 | 56 |
| 2014 September | 1 | 1 | 2 |
| 2014 June | 1 | 0 | 1 |
| 2014 May | 1 | 0 | 1 |
| 2014 March | 1 | 0 | 1 |
| 2014 January | 0 | 1 | 1 |
| 2013 September | 1 | 2 | 3 |
| 2013 July | 1 | 1 | 2 |
| 2013 June | 1 | 6 | 7 |
| 2013 April | 1 | 1 | 2 |
| 2013 February | 3 | 4 | 7 |
| 2013 January | 0 | 2 | 2 |
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