Ustekinumab y seguridad cardiovascular
Ustekinumab and Cardiovascular Safety
J.C. Ruiz-Carrascosa
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Especialista de Área de Dermatología. Coordinador Unidad de Psoriasis. Hospital Clínico Universitario San Cecilio. Granada. España
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Hospital Clínico Universitario San Cecilio. Granada. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ustekinumab and Cardiovascular Safety" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85092" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "MACES" 2 => "Psoriasis" 3 => "Seguridad cardiovascular" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85091" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "Major cardiovascular events" 2 => "Psoriasis" 3 => "Cardiovascular safety" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con psoriasis presentan un riesgo incrementado de accidentes cardiovasculares, y existe una correlación entre los fenómenos inmunológicos que ocurren en la psoriasis y otros procesos inflamatorios crónicos, como la ateromatosis. La aparición de eventos adversos cardiovasculares mayores en pacientes con psoriasis en placas en tratamiento con ustekinumab ha producido alarma en algunos autores; sin embargo, un análisis detallado de los estudios realizados confirma la seguridad cardiovascular de ustekinumab.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients with psoriasis have an increased risk of cardiovascular events, and there is evidence of a correlation between the immune processes that occur in psoriasis and those seen in other chronic inflammatory disorders such as atheromatous disease. The occurrence of major cardiovascular events in patients with plaque psoriasis being treated with ustekinumab caused alarm among some researchers, but a thorough analysis of the findings to date has confirmed the cardiovascular safety of this agent.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:68 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis and clinical features of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.E. Griffiths" 1 => "J.N. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 8 | 11 |
| 2024 October | 42 | 41 | 83 |
| 2024 September | 31 | 20 | 51 |
| 2024 August | 59 | 59 | 118 |
| 2024 July | 34 | 23 | 57 |
| 2024 June | 38 | 29 | 67 |
| 2024 May | 27 | 24 | 51 |
| 2024 April | 37 | 26 | 63 |
| 2024 March | 31 | 22 | 53 |
| 2024 February | 24 | 30 | 54 |
| 2024 January | 24 | 26 | 50 |
| 2023 December | 21 | 13 | 34 |
| 2023 November | 33 | 22 | 55 |
| 2023 October | 28 | 11 | 39 |
| 2023 September | 20 | 22 | 42 |
| 2023 August | 18 | 9 | 27 |
| 2023 July | 19 | 31 | 50 |
| 2023 June | 14 | 18 | 32 |
| 2023 May | 2 | 5 | 7 |
| 2023 April | 21 | 21 | 42 |
| 2023 March | 25 | 18 | 43 |
| 2023 February | 11 | 18 | 29 |
| 2023 January | 21 | 25 | 46 |
| 2022 December | 31 | 19 | 50 |
| 2022 November | 16 | 26 | 42 |
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| 2022 March | 17 | 56 | 73 |
| 2022 February | 17 | 39 | 56 |
| 2022 January | 24 | 56 | 80 |
| 2021 December | 18 | 34 | 52 |
| 2021 November | 36 | 33 | 69 |
| 2021 October | 76 | 45 | 121 |
| 2021 September | 38 | 67 | 105 |
| 2021 August | 27 | 35 | 62 |
| 2021 July | 26 | 32 | 58 |
| 2021 June | 22 | 25 | 47 |
| 2021 May | 24 | 37 | 61 |
| 2021 April | 32 | 71 | 103 |
| 2021 March | 24 | 19 | 43 |
| 2021 February | 17 | 22 | 39 |
| 2021 January | 18 | 17 | 35 |
| 2020 December | 17 | 18 | 35 |
| 2020 November | 16 | 18 | 34 |
| 2020 October | 22 | 15 | 37 |
| 2020 September | 6 | 8 | 14 |
| 2020 August | 12 | 16 | 28 |
| 2020 July | 13 | 14 | 27 |
| 2020 June | 23 | 17 | 40 |
| 2020 May | 28 | 33 | 61 |
| 2020 April | 17 | 17 | 34 |
| 2020 March | 14 | 16 | 30 |
| 2020 February | 0 | 1 | 1 |
| 2020 January | 0 | 1 | 1 |
| 2019 December | 0 | 1 | 1 |
| 2019 November | 0 | 5 | 5 |
| 2019 April | 0 | 2 | 2 |
| 2019 February | 0 | 3 | 3 |
| 2018 December | 0 | 3 | 3 |
| 2018 November | 0 | 4 | 4 |
| 2018 October | 0 | 1 | 1 |
| 2018 July | 0 | 1 | 1 |
| 2018 June | 0 | 3 | 3 |
| 2018 May | 0 | 9 | 9 |
| 2018 March | 0 | 2 | 2 |
| 2018 February | 7 | 8 | 15 |
| 2018 January | 10 | 6 | 16 |
| 2017 December | 9 | 8 | 17 |
| 2017 November | 15 | 10 | 25 |
| 2017 October | 11 | 6 | 17 |
| 2017 September | 7 | 9 | 16 |
| 2017 August | 8 | 9 | 17 |
| 2017 July | 8 | 4 | 12 |
| 2017 June | 15 | 14 | 29 |
| 2017 May | 14 | 17 | 31 |
| 2017 April | 20 | 19 | 39 |
| 2017 March | 26 | 22 | 48 |
| 2017 February | 12 | 18 | 30 |
| 2017 January | 17 | 22 | 39 |
| 2016 December | 14 | 15 | 29 |
| 2016 November | 20 | 19 | 39 |
| 2016 October | 25 | 11 | 36 |
| 2016 September | 25 | 18 | 43 |
| 2016 August | 36 | 19 | 55 |
| 2016 July | 16 | 15 | 31 |
| 2016 June | 0 | 4 | 4 |
| 2016 May | 0 | 14 | 14 |
| 2016 April | 0 | 2 | 2 |
| 2016 March | 0 | 4 | 4 |
| 2016 February | 0 | 4 | 4 |
| 2016 January | 0 | 12 | 12 |
| 2015 December | 3 | 17 | 20 |
| 2015 November | 7 | 15 | 22 |
| 2015 October | 8 | 21 | 29 |
| 2015 September | 6 | 14 | 20 |
| 2015 August | 14 | 9 | 23 |
| 2015 July | 26 | 2 | 28 |
| 2015 June | 25 | 5 | 30 |
| 2015 May | 56 | 22 | 78 |
| 2015 April | 34 | 17 | 51 |
| 2015 March | 44 | 7 | 51 |
| 2015 February | 49 | 13 | 62 |
| 2015 January | 35 | 14 | 49 |
| 2014 December | 35 | 9 | 44 |
| 2014 November | 33 | 16 | 49 |
| 2014 October | 39 | 25 | 64 |
| 2014 September | 1 | 1 | 2 |
| 2014 August | 1 | 1 | 2 |
| 2014 May | 1 | 0 | 1 |
| 2014 April | 3 | 0 | 3 |
| 2014 February | 1 | 0 | 1 |
| 2014 January | 0 | 1 | 1 |
| 2013 September | 0 | 1 | 1 |
| 2013 June | 0 | 1 | 1 |
| 2013 May | 1 | 1 | 2 |
| 2013 April | 3 | 1 | 4 |
| 2013 February | 0 | 1 | 1 |
| 2013 January | 0 | 1 | 1 |
Show all
