Field Treatment of Actinic Keratoses – Focus on COX-2-Inhibitors
Tratamiento del campo de queratosis actínicas: especial interés en los inhibidores de COX-2
M. Ulrich, E. Stockfleth
Corresponding author
eggert.stockfleth@charite.de
Correspondence: Department of Dermatology, Venerology and Allergy. Skin Cancer Centre Charité. Charitéplatz 1. 10117 Berlin, Germany.
Correspondence: Department of Dermatology, Venerology and Allergy. Skin Cancer Centre Charité. Charitéplatz 1. 10117 Berlin, Germany.
Department of Dermatology, Venerology and Allergy. Charité Universitätsmedizin. Berlin
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"apellidos" => "Stockfleth" "email" => array:1 [ 0 => "eggert.stockfleth@charite.de" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Department of Dermatology, Venerology and Allergy. Charité Universitätsmedizin. Berlin" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Department of Dermatology, Venerology and Allergy. Skin Cancer Centre Charité. Charitéplatz 1. 10117 Berlin, Germany." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento del campo de queratosis actínicas: especial interés en los inhibidores de COX-2" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82463" "palabras" => array:6 [ 0 => "actinic keratoses" 1 => "carcinoma <span class="elsevierStyleItalic">in situ</span>" 2 => "diclofenac" 3 => "hyaluronic acid" 4 => "apoptosis" 5 => "COX-2" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82464" "palabras" => array:6 [ 0 => "queratosis actínicas" 1 => "carcinoma intraepidérmico" 2 => "diclofenaco" 3 => "ácido hialurónico" 4 => "apoptosis" 5 => "COX-2" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Actinic keratoses (AK) represent the most common carcinoma <span class="elsevierStyleItalic">in situ</span> of the skin and show continuously increasing incidences worldwide. Clinically, AK occur as multiple lesions in sun-exposed areas, which has been referred to as field cancerization. Novel treatment modalities for actinic field cancerization include 3% diclofenac in 2.5% hyaluronic acid (HA). Recent investigations have gained insights in the mode of action of diclofenac in HA, showing that the induction of apoptosis is the major mode of action of this treatment.</p><p class="elsevierStyleSimplePara elsevierViewall">Herein, we give an overview about actinic keratosis focusing on treatment with the COX-2 inhibitor diclofenac 3% gel and summarize current concepts of its antineoplastic mode of action.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Las queratosis actínicas representan el carcinoma intraepidérmico más frecuente de la piel y muestran un incremento continuo de la incidencia mundialmente. Clínicamente, las queratosis actínicas aparecen de forma múltiple en áreas fotoexpuestas, lo que se conoce como campo de cancerización. Las nuevas opciones para el tratamiento del campo de cancerización actínico incluyen diclofenaco al 3% en ácido hialurónico al 2,5%. Investigaciones recientes han revelado el principal mecanismo de acción de diclofenaco, que consiste en la inducción de la apoptosis.</p><p class="elsevierStyleSimplePara elsevierViewall">En este artículo aportaremos una visión de conjunto sobre las queratosis actínicas, centrándonos en el tratamiento con un inhibidor de la enzima COX-2, diclofenaco al 3%, y resumiremos los conceptos actuales sobre su mecanismo de acción antineoplásico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 8 | 13 |
| 2024 October | 25 | 36 | 61 |
| 2024 September | 28 | 27 | 55 |
| 2024 August | 41 | 57 | 98 |
| 2024 July | 34 | 30 | 64 |
| 2024 June | 31 | 20 | 51 |
| 2024 May | 28 | 27 | 55 |
| 2024 April | 25 | 21 | 46 |
| 2024 March | 23 | 25 | 48 |
| 2024 February | 32 | 35 | 67 |
| 2024 January | 22 | 23 | 45 |
| 2023 December | 15 | 19 | 34 |
| 2023 November | 28 | 23 | 51 |
| 2023 October | 18 | 22 | 40 |
| 2023 September | 21 | 24 | 45 |
| 2023 August | 20 | 13 | 33 |
| 2023 July | 14 | 28 | 42 |
| 2023 June | 16 | 24 | 40 |
| 2023 May | 13 | 12 | 25 |
| 2023 April | 20 | 23 | 43 |
| 2023 March | 19 | 14 | 33 |
| 2023 February | 18 | 27 | 45 |
| 2023 January | 25 | 25 | 50 |
| 2022 December | 26 | 28 | 54 |
| 2022 November | 26 | 31 | 57 |
| 2022 October | 17 | 17 | 34 |
| 2022 September | 21 | 37 | 58 |
| 2022 August | 22 | 32 | 54 |
| 2022 July | 20 | 40 | 60 |
| 2022 June | 12 | 20 | 32 |
| 2022 May | 23 | 33 | 56 |
| 2022 April | 20 | 35 | 55 |
| 2022 March | 20 | 44 | 64 |
| 2022 February | 20 | 16 | 36 |
| 2022 January | 23 | 46 | 69 |
| 2021 December | 17 | 41 | 58 |
| 2021 November | 33 | 51 | 84 |
| 2021 October | 20 | 46 | 66 |
| 2021 September | 15 | 39 | 54 |
| 2021 August | 22 | 19 | 41 |
| 2021 July | 14 | 32 | 46 |
| 2021 June | 19 | 27 | 46 |
| 2021 May | 21 | 33 | 54 |
| 2021 April | 35 | 35 | 70 |
| 2021 March | 20 | 28 | 48 |
| 2021 February | 21 | 18 | 39 |
| 2021 January | 12 | 15 | 27 |
| 2020 December | 18 | 11 | 29 |
| 2020 November | 16 | 12 | 28 |
| 2020 October | 13 | 4 | 17 |
| 2020 September | 13 | 3 | 16 |
| 2020 August | 9 | 22 | 31 |
| 2020 July | 12 | 6 | 18 |
| 2020 June | 16 | 19 | 35 |
| 2020 May | 21 | 21 | 42 |
| 2020 April | 18 | 16 | 34 |
| 2020 March | 17 | 12 | 29 |
| 2020 February | 2 | 0 | 2 |
| 2019 May | 1 | 1 | 2 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 11 | 6 | 17 |
| 2018 January | 16 | 7 | 23 |
| 2017 December | 14 | 9 | 23 |
| 2017 November | 14 | 4 | 18 |
| 2017 October | 11 | 8 | 19 |
| 2017 September | 6 | 8 | 14 |
| 2017 August | 6 | 11 | 17 |
| 2017 July | 10 | 2 | 12 |
| 2017 June | 13 | 9 | 22 |
| 2017 May | 13 | 10 | 23 |
| 2017 April | 16 | 11 | 27 |
| 2017 March | 19 | 8 | 27 |
| 2017 February | 8 | 7 | 15 |
| 2017 January | 15 | 4 | 19 |
| 2016 December | 15 | 8 | 23 |
| 2016 November | 24 | 6 | 30 |
| 2016 October | 24 | 13 | 37 |
| 2016 September | 16 | 11 | 27 |
| 2016 August | 11 | 5 | 16 |
| 2016 July | 8 | 8 | 16 |
| 2016 June | 0 | 7 | 7 |
| 2016 May | 0 | 5 | 5 |
| 2016 April | 0 | 2 | 2 |
| 2016 February | 0 | 8 | 8 |
| 2016 January | 0 | 26 | 26 |
| 2015 December | 3 | 13 | 16 |
| 2015 November | 7 | 15 | 22 |
| 2015 October | 3 | 13 | 16 |
| 2015 September | 3 | 4 | 7 |
| 2015 August | 0 | 4 | 4 |
| 2015 July | 49 | 1 | 50 |
| 2015 June | 35 | 13 | 48 |
| 2015 May | 37 | 21 | 58 |
| 2015 April | 35 | 20 | 55 |
| 2015 March | 28 | 5 | 33 |
| 2015 February | 15 | 1 | 16 |
| 2015 January | 16 | 0 | 16 |
| 2014 December | 15 | 0 | 15 |
| 2014 November | 18 | 0 | 18 |
| 2014 October | 16 | 0 | 16 |
| 2014 September | 20 | 0 | 20 |
| 2014 August | 19 | 0 | 19 |
| 2014 July | 29 | 0 | 29 |
| 2014 June | 25 | 0 | 25 |
| 2014 May | 53 | 0 | 53 |
| 2014 April | 28 | 0 | 28 |
| 2014 March | 28 | 16 | 44 |
| 2014 February | 21 | 20 | 41 |
| 2014 January | 26 | 21 | 47 |
| 2013 December | 33 | 13 | 46 |
| 2013 November | 18 | 15 | 33 |
| 2013 October | 31 | 28 | 59 |
| 2013 September | 18 | 19 | 37 |
| 2013 August | 18 | 15 | 33 |
| 2013 July | 27 | 29 | 56 |
| 2013 June | 18 | 20 | 38 |
| 2013 May | 28 | 23 | 51 |
| 2013 April | 29 | 16 | 45 |
| 2013 March | 38 | 28 | 66 |
| 2013 February | 17 | 14 | 31 |
| 2013 January | 14 | 8 | 22 |
| 2012 December | 11 | 12 | 23 |
| 2012 November | 11 | 16 | 27 |
| 2012 October | 6 | 16 | 22 |
| 2012 September | 3 | 6 | 9 |
| 2012 August | 1 | 0 | 1 |
| 2010 November | 5 | 0 | 5 |
| 2010 October | 1 | 0 | 1 |
| 2010 September | 16 | 0 | 16 |
| 2010 August | 6 | 0 | 6 |
| 2010 July | 24 | 0 | 24 |
| 2010 June | 29 | 0 | 29 |
| 2010 May | 35 | 0 | 35 |
| 2010 April | 42 | 0 | 42 |
| 2010 March | 12 | 0 | 12 |
| 2010 January | 3 | 0 | 3 |
Show all
