Article information
Resumen
La psoriasis es una enfermedad crónica, que cursa por brotes, y que en un momento determinado de su evolución, o en ciertos pacientes, puede afectar una gran parte de la superficie corporal con graves repercusiones físicas y psíquicas. Los tratamientos utilizados en este tipo de pacientes se asocian a múltiples efectos secundarios y requieren numerosos controles clínicos y analíticos.
La aparición de las nuevas terapias biológicas en el arsenal terapéutico del dermatólogo ha aportado numerosas ventajas para el control y mantenimiento del paciente psoriásico. La facilidad de uso, limpieza, comodidad posológica y sencillez de su manejo han cambiado la perspectiva de la enfermedad. Su eficacia parece comparable o superior a la conseguida por terapias sistémicas clásicas como la fototerapia, los retinoides, metotrexato o ciclosporina.
Presentamos un caso clínico de psoriasis grave, que presentó una rápida y completa respuesta a etanercept. A propósito del mismo realizamos un revisión bibliográfica dirigida a los aspectos de seguridad y eficacia a corto plazo –menos de 12 semanas de tratamiento– en pacientes psoriásicos tratados con esta molécula.
Palabras clave:
Psoriasis
Etanercept
Eficacia
Seguridad
Abstract
Psoriasis is a chronic disease that occurs in episodes and which, in a certain moment of its evolution or in some patients, may affect a large portion of the body surface with serious physical and psychological repercussions. The treatment used in this type of patient is associated to many side effects and requires numerous clinical and laboratory controls.
The appearance of the new biological therapies in the therapeutic armamentum of the dermatologist has provided many advantages for the control and maintenance of the psoriatic patient. Their ease of use, cleanliness, dose comfort and ease-of-management have changed the patient's perspective. Their efficacy seems to be comparable or superior to those achieved by the classical systemic therapies such as phototherapy, retinoids, methotrexate or cyclosporine.
We present a clinical case of severe psoriasis that presented a rapid and complete response to etanercept. Based on this case, we performed a bibliographic review aimed at the short-term safety and efficacy aspects, less than 12 weeks of treatment, in psoriatic patients treated with this molecule.
Keywords:
Psoriasis
Etanercept
Efficacy
Safety
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