Actas Dermo-Sifiliográficas (English Edition) Actas Dermo-Sifiliográficas (English Edition)
Actas Dermosifiliogr 2017;108:e53-5 - Vol. 108 Num.8 DOI: 10.1016/j.adengl.2016.08.019
e- Case Report
Response to Omalizumab in Solar Urticaria: Report of 3 Cases
Respuesta a omalizumab en 3 casos de urticaria solar
P. Rodríguez-Jiménez, , P. Chicharro, A. Pérez-Plaza, D. de Argila
Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain
Abstract

We report 3 cases of solar urticaria in which there was no response or limited response to first-line treatments with high-dose H1 antihistamines or phototherapy. The patients were then treated with omalizumab. Symptoms improved in 2 patients, whose tolerance to sunlight increased considerably; quality of life clearly improved for 1 of these patients. The third experienced no improvement and developed a mild local reaction to the injected medication. We conclude that omalizumab may offer a potentially safe, useful alternative for patients with solar urticaria who do not respond to conventional therapy.

Resumen

Se presentan 3 pacientes con urticaria solar que o no habían respondido adecuadamente o presentaban limitaciones a los tratamientos de primera línea (antihistamínicos H1 a dosis altas o fototerapia), que fueron tratados con omalizumab. Dos de ellos mejoraron clínicamente con un aumento muy importante de la tolerancia a la luz, uno de ellos con clara mejoría de la calidad de vida. El otro paciente no mejoró y desarrolló una reacción local leve a la medicación inyectada. Omalizumab puede ser por tanto una alternativa terapéutica potencialmente útil y segura en urticarias solares graves no respondedoras al tratamiento convencional.

Keywords
Inducible chronic urticaria, Omalizumab, Solar urticaria
Palabras clave
Urticaria crónica inducible, Omalizumab, Urticaria solar

Article

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Actas Dermosifiliogr 2017;108:e53-5 - Vol. 108 Num.8 DOI: 10.1016/j.adengl.2016.08.019
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