Actas Dermo-Sifiliográficas (English Edition) Actas Dermo-Sifiliográficas (English Edition)
e-Case Report
Intralymphatic Histiocytosis: A Report of 2 Cases
Histiocitosis intralinfática, a propósito de 2 casos
M.E. Gómez-Sáncheza,, , J.M. Azaña-Defezb, M.L. Martínez-Martíneza, M.T. López-Villaescusac
a Servicio de Dermatología, Hospital General de Villarrobledo, Villarrobledo, Albacete, Spain
b Servicio de Dermatología, Hospital General de Albacete, Albacete, Spain
c Servicio de Dermatología, Hospital General de Almansa, Almansa, Albacete, Spain

Intralymphatic histiocytosis is a benign condition characterized by poorly defined erythematous plaques (sometimes forming a reticular pattern) as well as the presence of nodules and vesicles. Its etiology and pathogenesis appear to be related to chronic inflammation in the affected area, prior surgery, or systemic disease, particularly rheumatoid arthritis. We report on 2 new cases, both associated with joint surgery in the affected area and osteoarticular disease (primary synovial osteochondromatosis and rheumatoid arthritis). This is a chronic disease and there is no specific treatment. Different treatment options were chosen in the 2 cases described. A spectacular response to treatment with oral pentoxifylline and topical tacrolimus was observed in 1 of the patients.


La histiocitosis intralinfática es un proceso benigno caracterizado por placas eritematosas mal delimitadas, a veces reticuladas, otras con nódulos o vesículas en su interior. Su etiopatogenia parece estar relacionada con procesos inflamatorios crónicos en el área afectada, cirugía previa o con enfermedades sistémicas, sobre todo con la artritis reumatoide. Presentamos 2 nuevos casos, ambos asociados a cirugía articular del área afecta y enfermedad osteoarticular (osteocondromatosis sinovial primaria y artritis reumatoide). Esta entidad tiene un comportamiento crónico y no existe un tratamiento específico. En los 2 casos presentados se plantearon distintas opciones terapéuticas, mostrando uno de ellos una respuesta espectacular al tratamiento con pentoxifilina oral junto con tacrolimus tópico.

Intralymphatic histiocytosis, Reactive cutaneous angiomatosis, Rheumatoid arthritis, Treatment
Palabras clave
Histiocitosis intralinfática, Angiomatosis cutánea reactiva, Artritis reumatoide, Tratamiento


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