Actas Dermo-Sifiliográficas (English Edition) Actas Dermo-Sifiliográficas (English Edition)
Actas Dermosifiliogr 2017;108:721-8 - Vol. 108 Num.8 DOI: 10.1016/j.adengl.2017.01.005
Review
Advances in the Immunobiological Therapies for Advanced Melanoma
Nuevos avances de tratamiento inmunobiológico en el melanoma avanzado
M.C. Pérez Gago, O. Saavedra Santa Gadea, L. de la Cruz-Merino,
Servicio de Oncología Médica, Hospital Universitario Virgen Macarena, Sevilla, Spain
Received 24 April 2016, Accepted 09 January 2017
Abstract

Metastatic or locally advanced unresectable melanoma carries a high morbidity and mortality. However, notable advances have been made in recent years in the systemic treatment of this disease, with the appearance of targeted therapy using tyrosine kinase inhibitors that block the mitogen activated protein kinase pathway, and of modern immunotherapy with immune-modulating monoclonal antibodies. In this paper, we provide an update of available data on new immune therapies and we review the clinical development that led to their approval for use in routine clinical practice.

Resumen

El melanoma irresecable localmente avanzado y metastásico es una situación clínica asociada a una elevada tasa de morbimortalidad. En los últimos años, sin embargo, han acontecido notables avances en el ámbito del tratamiento sistémico de esta enfermedad, con la irrupción de la terapia dirigida con inhibidores tirosincinasa que actúan bloqueando la vía de las MAPKinasas, y de la moderna inmunoterapia con anticuerpos monoclonales inmunomoduladores. En la presente revisión se realiza una actualización sobre los datos disponibles con los nuevos inmunoterápicos, así como un repaso del desarrollo clínico que ha permitido la aprobación para su uso en la práctica clínica habitual.

Keywords
Melanoma, Antibodies, Immunomodulators, Anti-CTLA4, Anti-PD1
Palabras clave
Melanoma, Anticuerpos, Inmunomoduladores, Anti-CTLA4, Anti-PD1

Article

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Actas Dermosifiliogr 2017;108:721-8 - Vol. 108 Num.8 DOI: 10.1016/j.adengl.2017.01.005
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