Actas Dermo-Sifiliográficas (English Edition) Actas Dermo-Sifiliográficas (English Edition)
Actas Dermosifiliogr 2017;108:708-20 - Vol. 108 Num.8 DOI: 10.1016/j.adengl.2017.07.001
Review
Novel Immunologic Approaches to Melanoma Treatment
Novedades en inmunología del melanoma
I. Escandell, , J.M. Martín, E. Jordá
Servicio de Dermatología, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain
Received 18 May 2016, Accepted 31 January 2017
Abstract

Approaches to treating melanoma have changed radically since the introduction of immunotherapy, and survival figures are now higher than possible with earlier therapies. The immunomodulators currently available mainly block CTLA-4 (cytotoxicT lymphocyte-associated molecule-4) and PD-1 (programed cell death protein 1) translocated to the cell surface, where they inhibit the antitumor immune response. Treatments blocking these molecules are being more widely used. Research now seeks new molecular targets, the best combinations of available drugs, and biomarkers that can identify ideal candidates for each one

Resumen

Desde la introducción de la inmunoterapia el tratamiento del melanoma ha sufrido una revolución, consiguiéndose cifras de supervivencia superiores a las que se alcanzaban con los tratamientos previos. Los fármacos inmunomoduladores disponibles actualmente van dirigidos principalmente frente a las moléculas de superficie CTLA-4 y PD-1, que ejercen un efecto inhibidor sobre la respuesta inmune antitumoral. Se trata de un tratamiento en pleno proceso de expansión, y la investigación se dirige hacia el descubrimiento de nuevas moléculas, las combinaciones de los fármacos disponibles o la identificación de biomarcadores que permitan seleccionar a los pacientes idóneos para cada terapia.

Keywords
Melanoma, Clinical oncology, Immunology, Immunotherapy
Palabras clave
Melanoma, Oncología clínica, Inmunología, Inmunoterapia

Article

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Actas Dermosifiliogr 2017;108:708-20 - Vol. 108 Num.8 DOI: 10.1016/j.adengl.2017.07.001
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