Actas Dermo-Sifiliográficas (English Edition) Actas Dermo-Sifiliográficas (English Edition)
Actas Dermosifiliogr 2017;108:174-5 - Vol. 108 Num.2 DOI: 10.1016/j.adengl.2016.12.017
Letter to the Editor
Comment on “Distant Cutaneous Metastases of Prostate Cancer: A Report of 2 Cases”
Comentario a «Metástasis cutáneas a distancia de cáncer de próstata: 2 casos»
J. Santos-Juanesa,, , I. Fernández-Vegab, B. Vivancob
a Servicio de Dermatología II, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
To the Editor:

We read with interest the article entitled “Distant cutaneous metastases of prostate cancer: a report of 2 cases”1 in which an exhaustive immunohistochemical study left no doubt about the diagnosis. These cases remind us of usefulness of avian erythroblastosis virus E26 oncogene homolog (ERG) in the cutaneous diagnosis of prostate cancer metastasis.

ERG is a member of the erythroblast transformation-specific family of transcription factors. It is expressed in normal and neoplastic endothelial cells of blood and lymph vessels and is a highly specific marker of vascular endothelium. ERG is very useful in the diagnosis of angiosarcomas, hemangioendotheliomas, and Kaposi's sarcoma. However, it is also positive in the following cell types: 1) neoplastic epithelial cells of 50% of primary and metastatic prostate carcinomas (Figure 1), but not in normal prostate tissue; 2) immature myeloid cells in bone marrow; 3) chronic myeloid leukemia cells; and 4) Ewing sarcoma cells.2 The fact that it is positive in prostate carcinoma but negative in almost all other carcinomas makes ERG a very valuable in immunohistochemical panels used to investigate cutaneous metastases of unknown origin.3

Figure 1.
(0.21MB).

Subcutaneous nodule in right paravertebral back (ERG×200, nuclear staining).

References
1
R. Rodríguez-Lojo,I. Castiñeiras,J.L. Rey-Sanjurjo,M.L. Fernández-Díaz
Metástasis cutáneas a distancia de cáncer de próstata: 2 casos
Actas Dermosifiliogr, 107 (2016), pp. e52-e56 http://dx.doi.org/10.1016/j.ad.2015.09.021
2
M. Miettinen,Z.F. Wang,A. Paetau,S.H. Tan,A. Dobi,S. Srivastava
ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma
Am J Surg Pathol, 35 (2011), pp. 432-441 http://dx.doi.org/10.1097/PAS.0b013e318206b67b
3
L. Fuertes,C. Santonja,H. Kutzner,L. Requena
Inmunohistoquímica en dermatopatología: revisión de los anticuerpos utilizados con mayor frecuencia (parte I)
Actas Dermosifiliogr, 104 (2013), pp. 99-127 http://dx.doi.org/10.1016/j.ad.2012.02.015

Please cite this article as: Santos-Juanes J, Fernández-Vega I, Vivanco B. Comentario a «Metástasis cutáneas a distancia de cáncer de próstata: 2 casos». Actas Dermosifiliogr. 2017;108:174–175.


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Copyright © 2016. Elsevier España, S.L.U. and AEDV
Actas Dermosifiliogr 2017;108:174-5 - Vol. 108 Num.2 DOI: 10.1016/j.adengl.2016.12.017