Actas Dermo-Sifiliográficas (English Edition) Actas Dermo-Sifiliográficas (English Edition)
Actas Dermosifiliogr 2018;109:399-407 - Vol. 109 Num.5 DOI: 10.1016/j.adengl.2018.04.019
Adult T-Cell Leukemia/Lymphoma. Review of the Literature
Leucemia/linfoma de células T del adulto. Revisión de la literatura científica
M.J.M. Rodríguez-Zúñigaa,b,, , , , F. Cortez-Francoa, E. Qujiano-Gomeroa
a Servicio de Dermatología, Hospital Nacional Daniel Alcides Carrión, Callao, Perú
b Universidad Nacional Mayor de San Marcos, Lima, Perú
Received 04 November 2016, Accepted 03 August 2017

Adult T-cell Leukemia/Lymphoma (ATLL) is an aggressive neoplasm of T lymphocytes associated with Human T-lymphotropic virus type1 (HTLV-1) infection. HTLV-1 is a public health problem because it is endemic in native groups in Latin America, and its infection leads to several chronic diseases as ATLL. We aimed to review current literature of ATLL in order to consider it as a differential diagnosis in front of patients with compatible symptoms. Prognosis is still poor in aggressive and indolent variants, with survival rates from months to few years. Treatment based on chemotherapy, antiretroviral, and allogenic stem cell transplantation are currently improving survival rates, but with limited results.


La leucemia/linfoma de células T del adulto (LLCTA) es una neoplasia agresiva de los linfocitos T asociada a la infección del virus humano T linfotrófico tipo1 (HTLV-1). El HTLV-1 es un problema de salud pública ya que es endémico en etnias nativas de América del Sur, y su infección conlleva diversas enfermedades crónicas, tal como la LLCTA. Nuestro objetivo fue revisar la literatura más reciente sobre LLCTA para su consideración como diagnóstico diferencial ante hallazgos clínicos compatibles. El pronóstico de esta enfermedad es aún malo en las variantes agresivas e indolentes, con sobrevida desde meses a pocos años. El tratamiento, que actualmente se basa en quimioterapia, antirretrovirales y trasplante alogénico de médula ósea, ha mejorado dichos índices de sobrevida, pero aún con resultados limitados.

Adult T-cell leukemia/lymphoma, Human T lymphotropic virus type1, Case report, Review, Epidemiology, Treatment, Prognosis, Latin America
Palabras clave
Leucemia/linfoma de células T del adulto, Virus humano T linfotrófico tipo1, Informe de caso, Revisión, Epidemiología, Tratamiento, Pronóstico, América Latina


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Actas Dermosifiliogr 2018;109:399-407 - Vol. 109 Num.5 DOI: 10.1016/j.adengl.2018.04.019
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