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Vol. 109. Num. 1.January - February 2018
Pages e1-e6Pages 1-94
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Vol. 109. Num. 1.January - February 2018
Pages e1-e6Pages 1-94
Review
DOI: 10.1016/j.adengl.2017.11.003
Treatment of Malignant Cutaneous Adnexal Neoplasms
Tratamiento de las neoplasias anexiales cutáneas malignas
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C. Bernárdez
Corresponding author
cbernardez@fjd.es

Corresponding author.
, L. Requena
Servicio de Dermatología, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, España
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Tables (2)
Table 1. Histopathologic Differential Diagnosis Between Benign and Malignant Adnexal Neoplasms.
Table 2. Classification of Malignant Adnexal Neoplasms According to Type of Differentiation.
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Abstract

Malignant cutaneous adnexal neoplasms form a group of rare, typically low-grade-malignancy carcinomas with follicular, sebaceous, apocrine, or eccrine differentiation or a combination of the first 3 subtypes. Their clinical presentation is usually unremarkable, and biopsy is required to establish the differentiation subtype and the definitive diagnosis. Due to their rarity, no clear consensus has been reached on which treatment is most effective. Mohs micrographic surgery is considered to be the best option to prevent recurrence in the majority of patients. Radiotherapy and chemotherapy have been studied in very few cases and have rarely been shown to be effective.

Keywords:
Malignant cutaneous adnexal neoplasms
Treatment
Surgery
Mohs micrographic surgery
Resumen

Las neoplasias anexiales cutáneas malignas constituyen un grupo de carcinomas poco frecuentes, habitualmente de bajo grado de malignidad, que muestran diferenciación folicular, sebácea, apocrina o ecrina o una combinación de las 3 primeras. Clínicamente suelen ser neoplasias con características poco distintivas, siendo necesaria una biopsia que permitirá establecer el tipo de diferenciación y el diagnóstico definitivo. Al tratarse de una enfermedad poco frecuente, no existe un claro consenso sobre el tratamiento más eficaz. En la mayoría de casos se considera la microcirugía de Mohs como la opción más efectiva para prevenir recidivas. La radioterapia y quimioterapia han sido escasamente estudiadas y solo se han mostrado eficaces en escasas ocasiones.

Palabras clave:
Neoplasias anexiales cutáneas malignas
Tratamiento
Cirugía
Cirugía de Mohs

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