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Vol. 108. Num. 9.November 2017
Pages e57-e62Pages 795-888
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Vol. 108. Num. 9.November 2017
Pages e57-e62Pages 795-888
Review
DOI: 10.1016/j.adengl.2017.08.020
Nonsurgical Therapies for Basal Cell Carcinoma: A Review
Terapias no quirúrgicas para el carcinoma basocelular: revisión
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S. Ariza, S. Espinosa
Corresponding author
, M. Naranjo
Servicio de Dermatología, Hospital San José, Fundación Universitaria de Ciencias de la Salud, FUCS, Bogotá, Colombia
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Tables (5)
Table 1. Characteristics of the Systematic Reviews and Meta-Analyses Analyzed in Our Review.
Table 2. Data on Clinical Trials Not Included in the Systematic Reviews.
Table 3. Classification of Basal Cell Carcinoma According to Risk of Recurrence.
Table 4. Nonsurgical Treatment Options for BCC.
Table 5. Adverse Events Reported for Smoothened Inhibitors Vismodegib and Sonidegib.
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Abstract

Basal cell carcinoma (BCC) is the most prevalent malignant tumor in humans and the local destruction of tissue that can result from excision has a significant impact on well-being. Treating BCC is costly for health care systems given the high incidence of this tumor, especially in older patients. Standard treatment involves either resection with histologic assessment of margins or Mohs micrographic surgery. Surgery is sometimes contraindicated, however, due to the presence of significant comorbidity or high cosmetic expectations. For such patients, nonsurgical treatments have become available. These alternatives can offer good local control of disease, preserve function, and achieve excellent cosmetic results.

Keywords:
Basal cell carcinoma
Skin cancer
Treatment
Resumen

El carcinoma basocelular (CBC) es el tumor maligno más frecuente en seres humanos, y tiene la capacidad de causar una significativa morbilidad asociada a su potencial de destrucción local. El tratamiento del CBC demanda altos costes de atención para los sistemas de salud, por la gran incidencia de esta enfermedad, especialmente en pacientes mayores. El tratamiento estándar para la mayoría de los CBC consiste en la resección quirúrgica con márgenes y control histológico de los bordes de sección, o mediante cirugía micrográfica de Mohs. Sin embargo, en algunos pacientes con contraindicación para cirugía, que tienen comorbilidades importantes o altas expectativas estéticas, existen en la actualidad nuevas alternativas terapéuticas no quirúrgicas, con las cuales se puede lograr muy buen control local, preservar la función y obtener un excelente resultado cosmético.

Palabras clave:
Carcinoma basocelular
Cáncer de piel
Tratamiento

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