Lichenoid Drug Eruption Induced by Olanzapine

Fernández-Torres, R.; Almagro, M.; del Pozo, J.; Robles, O.; Martínez-González, C.; Mazaira, M.; Fonseca, E.

doi:10.1016/S1578-2190(08)70236-1

Actas Dermo-Sifiliográficas

ISSN: 0001-7310

The Official publication of the Spanish Academy of Dermatology and Venereology (AEDV). Actas Dermo-Sifiliográficas, founded in 1909, is the oldest monthly medical journals published in Spain. In the year 2006 has been indexed in the Medlinedatabase, and has become a vehicle for expressing the most current Spanish medicine and modern. All articles are subjected to a rigorous process of revision in pairs, and careful editing for literary and scientific style. Together with the classic Original and Clinical Case Study sections, we also include Reviews, Case Diagnoses, and Book Reviews. Dermo-Sifiliográficas is an essential publication for anyone who needs to be current on all aspects of Spanish and world dermatology.

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Web of Science, Emerging Sources Citation Index (WoS, Clarivate), PubMed/Medlinee, IME, Embase/Excerpta Medica, Embase, Toxline, Cab Abstracts, Cab Health, Cancerlit NIm, Serline: Biomed, Bibliomed, Pascal, Scopus , IBECS

Lichenoid drug eruptions can mimic idiopathic lichen planus and other dermatoses. The list of drugs that can cause them is long and growing steadily. Although cutaneous side effects of antipsychotics are rare, various cutaneous manifestations have been reported in association with olanzapine. We present the case of a patient who developed an atypical lichenoid eruption due to olanzapine. A review of the literature in Medline from 1951 to 2007 and in the Índice Médico Español (Spanish Medical Index) revealed no previous cases of lichenoid eruptions associated with the use of this drug.

Key words:

olanzapine

lichenoid drug eruption

lichen planus

Resumen

Las erupciones liquenoides inducidas por fármacos pueden simular un liquen plano idiopático y otras dermatosis. La lista de fármacos que pueden inducirlas es amplia y se incrementa constantemente. Aunque los efectos secundarios cutáneos en relación con antipsicóticos son raros, se han descrito diversas manifestaciones cutáneas en relación con la olanzapina.

Presentamos el caso de una paciente que desarrolló una erupción liquenoide atípica debida a olanzapina. En la revisión de la literatura que hemos realizado (Medline desde 1951 hasta 2007 e Índice Médico Español) no hemos encontrado ningún caso descrito de erupción liquenoide relacionado con este fármaco.

Palabras clave:

olanzapina

erupción liquenoide por fármacos

liquen plano

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